Evidence map›Paper›PMID 26623414›Full record

ArticleObstetrics & gynecology science2015

Maternal antimullerian hormone as a predictor of fetal aneuploidy occurring in an early pregnancy loss.

So Hyun Shim, Hyeong In Ha, Yong Wook Jung, Sung Shin Shim, Yeon Kyung Cho, Ji Youn Kim, Kyoung Jin Lee, Dong Hyun Cha, Soo Hyun Kim, Hee Jin Park

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obstetrics & gynecology science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

So Hyun ShimDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
Hyeong In HaDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
Yong Wook JungDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
Sung Shin ShimDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
Yeon Kyung ChoDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
Ji Youn KimDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
Kyoung Jin LeeDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
Dong Hyun ChaDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
Soo Hyun KimDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
Hee Jin ParkDepartment of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
CHA University Gangnam Medical Center · KRCHA University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of the study was to examine the relationship between the parameter representing ovarian reserve and the fetal aneuploidy in early spontaneous miscarriage.

methodsA multicenter retrospective cohort study was performed in patients who were diagnosed with early pregnancy loss (≤13 gestational weeks) and examined for fetal karyotype at the CHA Gangnam Medical Center, CHA Bundang Medical Center, and CHA Gumi Medical Center between January 2011 and December 2012. Karyotyping was performed by the Genetic Laboratory of the Fertility Center of CHA Gangnam Medical Center. Medical records were reviewed for demographics, karyotype analysis and hormonal assay of ovarian reserve including antimullerian hormone (AMH) and follicle stimulating hormone. Statistical analysis was performed using SPSS software.

resultsA total 462 patients were included in this study. The mean age of the patients was 35.31±4.12 years and the mean AMH level was 3.88±3.50 ng/mL (n=195). Two hundred eleven conceptuses (45.7%) of patients showed the euploid and 251 (54.3%) showed the aneuploid. There are significant differences in maternal age, AMH and gestational age between fetal euploid and aneuploid groups (34.46±4.35 vs. 36.04±3.78 years, P<0.001; 4.60±3.86 vs. 3.43±3.18 ng/mL, P=0.022; 7.67±1.54 vs. 8.27±1.46 weeks, P<0.001, respectively). Multivariate analysis revealed that low AMH level and early gestational age were maternal age-independent markers for fetal aneuploid (P<0.001 and P=0.045, respectively).

conclusionLow maternal AMH level might be a predicting marker for fetal aneuploid in early pregnancy loss.

Indexed as

Abortion, spontaneousAneuploidyAnti-mullerian hormoneChromosome aberrationsFollicle stimulating hormone

Identifiers

PMID26623414
PMCPMC4663228
OpenAlexW2179110131

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.