ArticleResults in immunology2015
Predictive value of antinuclear antibodies in autoimmune diseases classified by clinical criteria: Analytical study in a specialized health institute, one year follow-up.
Article in Results in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Identifying antinuclear antibody positive individuals at risk for developing systemic autoimmune disease: development and validation of a real-time risk model.Frontiers in immunology · 2024Article
- Chasing the Zebra: a case of membranous-like Glomerulopathy with SSA/RO52 deposits and no overt connective tissue disease.BMC rheumatology · 2023Article
- Comparison of Indirect Immunofluorescence and Enzyme Immunoassay for the Detection of Antinuclear Antibodies.Cureus · 2022Article
- Effect of antinuclear antibodies on pharmacokinetics of anti-TNF therapy in patients with inflammatory bowel disease.International journal of colorectal disease · 2022Article
- Sex-Specific Associations Between Serum Lipids, Antinuclear Antibodies, and Statin Use in National Health and Nutrition Examination Surveys 1999-2004.Frontiers in medicine · 2022Article
- The impact of education and clinical decision support on the quality of positive antinuclear antibody referrals.Clinical rheumatology · 2021Article
- Serum IgG Profiling of Toddlers Reveals a Subgroup with Elevated Seropositive Antibodies to Viruses Correlating with Increased Vaccine and Autoantigen Responses.Journal of clinical immunology · 2021Article
- Assessment of antinuclear antibodies (ANA): National recommendations on behalf of the Croatian society of medical biochemistry and laboratory medicine.Biochemia medica · 2021Review
- Stratification of Nuclear Homogeneous Patterns on HEp-2 Cells Based on Neutrophil Nuclear Staining.Chonnam medical journal · 2021Article
- A Hospital-Based Insight into the Antinuclear Antibody Patterns in Autoimmune Disorders.Journal of laboratory physicians · 2020Article
- Investigation and analysis of HEp 2 indirect immunofluorescence titers and patterns in various liver diseases.Clinical rheumatology · 2020Article
- E-consults: an effective way to decrease clinic wait times in rheumatology.BMC rheumatology · 2020Article
- Article
- Autoimmune markers for progression of Libby amphibole lamellar pleural thickening.Inhalation toxicologyArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDetermination of antinuclear antibodies (ANA) by indirect immunofluorescence (IIF) is usually the initial test for the diagnosis of systemic rheumatic diseases (SRD). Assigning predictive values to positive and negative results of the test is vital because lack of knowledge about ANAs and their usefulness in classification criteria of SRD leads to inappropriate use.
methodsRetrospective study, ANA tests requested by different specialties, correlation to patients' final diagnosis.
resultsThe prevalence of autoimmune disease was relatively low in our population yielding a low PPV and a high NPV for the ANA test. 40% of the patients had no clinical criteria applied prior to test. Coexistence of two or more autoimmune disorders affects prevalence and predictive values.
conclusionApplication of the test after careful evaluation for clinical criteria remarkably improves the positive likelihood ratio for the diagnosis.
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