ReviewJournal of thoracic disease2015
Red blood cell distribution width and cardiovascular diseases.
Review in Journal of thoracic disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers.
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Who cites it
141 citing papers in PubMed, 229 citations in OpenAlex.
- Red Cell Distribution Width is Associated with Future Incidence of Abdominal Aortic Aneurysm in a Population-Based Cohort Study.Scientific reports · 2020Trial
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- Red Cell Distribution Width-Standard Deviation and the Severity of In-Stent Restenosis: Associations with Angiographic Stenosis Burden and Mehran Classification.Medicina (Kaunas, Lithuania) · 2026Observational
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- Associations between haemoglobin-to-red cell distribution width ratio and mortality in intracerebral haemorrhage: a population-based analysis of the MIMIC-IV database.Journal of global health · 2026Article
- Red blood cell distribution width and blood transfusions are associated with 2-year mortality after transcatheter aortic valve implantation in males but not in females: sex-related differences in hematological predictors.Internal and emergency medicine · 2026Article
- Elevated Red Blood Cell Distribution Width Predicts Mortality and Major Adverse Cardiovascular Events After Acute Myocardial Infarction: A Large Propensity Score-Matched Cohort Study.Journal of clinical medicine · 2026Article
- Association between hemoglobin-to-red blood cell distribution width ratio and 28-day all-cause mortality in patients with acute kidney injury: A cross-sectional study.The Journal of international medical research · 2026Article
- Red cell distribution width positively correlates with 10-year risk of cardiovascular disease among people with type 1 diabetes as assessed by the Steno Type 1 Risk Engine.Acta diabetologica · 2026Article
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- Red blood cell distribution width is associated with coronary artery disease in latent tuberculosis infection: a machine learning-based study.Frontiers in cellular and infection microbiology · 2026Article
- Web-based cardiovascular disease risk prediction using machine learning.Frontiers in artificial intelligence · 2026Article
- HearteXplain: explainable prediction of acute heart failure and identification of hematologic biomarkers using EBMs and Morris sensitivity analysis.Scientific reports · 2025Article
- Red Blood Cell Distribution and Volume Changes at Capillary Junctions in the Living Human Retina.Investigative ophthalmology & visual science · 2025Article
- Red Blood Cell Membrane Lipidomics: Potential Biomarkers Detecting Method for Plasma Volume Overload and Major Adverse Cardiovascular Events in Chronic Heart Failure Patients.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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- Red Blood Cells and Human Aging: Exploring Their Biomarker Potential.Diagnostics (Basel, Switzerland) · 2025Review
- Association between red cell distribution width-to-albumin ratio and In-hospital mortality in patients with acute exacerbation of chronic obstructive pulmonary disease and respiratory failure: a retrospective cohort study.Biomarkers in medicine · 2025Article
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81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe red blood cell distribution width (RDW) is a rather simple measure of red blood cell (RBC) size heterogeneity (i.e., anisocytosis), which is easily calculated by dividing the standard deviation (SD) of erythrocyte volumes for the mean corpuscular volume (MCV). Emerging evidence suggests that, besides RBC abnormalities, many human disorders may be frequently associated with a high degree of anisocytosis.
methodsIn this narrative review, we analyzed the current scientific literature about the putative role and the potential epidemiologic association between RDW and cardiovascular diseases. The findings of the most representative epidemiological studies were summarized and discussed.
resultsOverall, considerable and convincing evidence has been brought that an increased RDW value is associated with acute coronary syndrome (ACS) [including acute myocardial infarction (AMI)], ischemic cerebrovascular disease (including stroke), peripheral artery disease (PAD), as well as with atrial fibrillation (AF), heart failure (HF) and hypertension. Higher anisocytosis also significantly and independently predicts adverse outcomes in patients with these conditions.
conclusionsAlthough the role of anisocytosis in the pathogenesis of cardiovascular diseases remains uncertain, the considerable evidence available so far suggests that the clinical use of RDW may be broadened beyond the conventional boundaries of erythrocyte disorders, in particular for assisting the diagnosis and prognostication of patients with ACS, ischemic cerebrovascular disease, PAD, HF and AF.
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