Evidence map›Paper›PMID 26623108›Full record

ArticleJournal of thoracic disease2015

Characterization of a new subtype of allergen in dermatophagoides farinae-Der f 28.

Jian-Li Lin, Yuan-Yuan Wang, Xiao-Jun Xiao, Yu-Lan Wu, Bao-Qing Sun, An-Jian Gao, Zhi-Gang Liu, Jing Li, Ping-Chang Yang, Xiao-Yu Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jian-Li Lin1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
Yuan-Yuan Wang1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
Xiao-Jun Xiao1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
Yu-Lan Wu1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
Bao-Qing Sun1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
An-Jian Gao1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
Zhi-Gang Liu1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
Jing Li1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
Ping-Chang Yang1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
Xiao-Yu Liu1 State Key Laboratory of Respiratory Disease for Allergy, School of Medicine, Shenzhen University, Shenzhen 518060,, China ; 2 State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
First Affiliated Hospital of Guangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHouse dust mites (HDMs) are the major sources of indoor allergens which induce asthma, dermatitis, rhinitis, and some other allergic diseases. Close to 30 sub-allergens have been identified.

methodsThrough analyzing the full genome sequence of dust mite, a new allergen whose primary structure belongs to the heat shock protein family was identified. The sequence of this allergen was determined by cDNA cloning. The allergenicity was assayed by skin prick test, Western-blot and enzyme-linked immunosorbent assay (ELISA).

resultsr-Der f 28 bound to serum IgE from mite allergic patients. Positive responses to r-Der f 28 were shown in 11.5% by skin prick testing from 26 DM-allergic patients. Airway hyperresponsiveness, serum specific IgE and IL-4 were significantly increased in allergic asthma mouse model sensitized to r-Der f 28.

conclusionsDer f 28 is a new subtype of allergen in dermatophagoides farinae.

Indexed as

allergic asthmaDer f 28Dermatophagoides farinaeenzyme-linked immunosorbent assay (ELISA)mouse modelskin prick testwestern-blotting

Identifiers

PMID26623108
PMCPMC4635255
OpenAlexW1934748188

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.