Evidence map›Paper›PMID 26622892›Full record

ArticleOncology letters2015

Anti-inflammatory drugs and uterine cervical cancer cells: Antineoplastic effect of meclofenamic acid.

Alejandro D Soriano-Hernandez, Daniela Madrigal-Pérez, Hector R Galvan-Salazar, Margarita L Martinez-Fierro, Laura L Valdez-Velazquez, Francisco Espinoza-Gómez, Oscar F Vazquez-Vuelvas, Bertha A Olmedo-Buenrostro, Jose Guzman-Esquivel, Iram P Rodriguez-Sanchez and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Alejandro D Soriano-HernandezSchool of Medicine, University of Colima, Colima, Colima 28030, Mexico ; Cancerology State Institute, Colima State Health Services, Colima, Colima 28000, Mexico.
Daniela Madrigal-PérezSchool of Medicine, University of Colima, Colima, Colima 28030, Mexico.
Hector R Galvan-SalazarSchool of Medicine, University of Colima, Colima, Colima 28030, Mexico ; Cancerology State Institute, Colima State Health Services, Colima, Colima 28000, Mexico.
Margarita L Martinez-FierroMolecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autononous University of Zacatecas, Zacatecas, Zacatecas 98160, Mexico.
Laura L Valdez-VelazquezSchool of Chemistry, University of Colima, Coquimatlán, Colima 28400, Mexico.
Francisco Espinoza-GómezSchool of Medicine, University of Colima, Colima, Colima 28030, Mexico.
Oscar F Vazquez-VuelvasSchool of Chemistry, University of Colima, Coquimatlán, Colima 28400, Mexico.
Bertha A Olmedo-BuenrostroSchool of Medicine, University of Colima, Colima, Colima 28030, Mexico.
Jose Guzman-EsquivelGeneral Hospital of Zone No. 1, Mexican Institute of Social Security, Colima, Colima 28000, Mexico.
Iram P Rodriguez-SanchezDepartment of Genetics, School of Medicine, Nuevo Leon Autonomous University, Monterrey, Nuevo León 64460, Mexico.
Agustin Lara-EsquedaCancerology State Institute, Colima State Health Services, Colima, Colima 28000, Mexico.
Daniel A Montes-GalindoSchool of Medicine, University of Colima, Colima, Colima 28030, Mexico ; School of Chemistry, University of Colima, Coquimatlán, Colima 28400, Mexico.
Ivan Delgado-EncisoSchool of Medicine, University of Colima, Colima, Colima 28030, Mexico ; Cancerology State Institute, Colima State Health Services, Colima, Colima 28000, Mexico.
Universidad de Colima · MXUniversidad Autónoma de Nuevo León · MXUniversidad Autónoma de Zacatecas "Francisco García Salinas" · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uterine cervical cancer (UCC) is one of the main causes of cancer-associated mortality in women. Inflammation has been identified as an important component of this neoplasia; in this context, anti-inflammatory drugs represent possible prophylactic and/or therapeutic alternatives that require further investigation. Anti-inflammatory drugs are common and each one may exhibit a different antineoplastic effect. As a result, the present study investigated different anti-inflammatory models of UCC in vitro and in vivo. Celecoxib, sulindac, nimesulide, dexamethasone, meclofenamic acid, flufenamic acid and mefenamic acid were tested in UCC HeLa, VIPA, INBL and SiHa cell lines. The cytotoxicity of the drugs was evaluated

Indexed as

antitumor activitymeclofenamic acidmurine modelnon-steroidal anti-inflamatory drugsuterine cervical cancer

Identifiers

PMID26622892
PMCPMC4580029
OpenAlexW2131770286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.