Evidence map›Paper›PMID 26622657›Full record

ArticleOncology letters2015

Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis.

Lin Ye, Yongning Jia, K E Ji, Andrew J Sanders, Kan Xue, Jiafu Ji, Malcolm D Mason, Wen G Jiang

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05641506 (An Open-label, Phase II Clinical Trial of of a Chinese Patent Medicine Yangzhengxiaoji Capsule to Improve the Adverse Reactions Nausea of Niraparib in in the First-line Maintenance Treatment in Advanced Epithelial Ovarian Cancer), which is not on this map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05641506 phase2unknown statusnot on this mapstarted 2022, after this paper: background citation

An Open-label, Phase II Clinical Trial of of a Chinese Patent Medicine Yangzhengxiaoji Capsule to Improve the Adverse Reactions Nausea of Niraparib in in the First-line Maintenance Treatment in Advanced Epithelial Ovarian Cancer (EOC) Patients

TypeinterventionalSponsorSichuan Cancer Hospital and Research InstituteRan2022 to 2025Enrolled50ConditionsOvarian CancerArmsYangzheng Xiaoji, Niraparib
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 165 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Potential Active Compounds ofFood science & nutrition · 2025
    Review
  5. Article
  6. Article
  7. Chinese herbal medicines · 2025
    Review
  8. Review
  9. Article
  10. Anti‑proliferative effects ofOncology letters · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Lin YeCardiff University-Peking University Cancer Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK ; Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK ; Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Yongning JiaCardiff University-Peking University Cancer Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK ; Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK ; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Haidian, Beijing 100142, P.R. China.
K E JiCardiff University-Peking University Cancer Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK ; Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK ; Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Andrew J SandersCardiff University-Peking University Cancer Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK ; Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK ; Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Kan XueKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Haidian, Beijing 100142, P.R. China.
Jiafu JiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Haidian, Beijing 100142, P.R. China.
Malcolm D MasonInstitute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Wen G JiangCardiff University-Peking University Cancer Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK ; Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK ; Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Cardiff University · GBPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional Chinese medicine (TCM) has been a major part of healthcare in China, and has extensively affected medicine and healthcare in surrounding countries over a long period of time. In the fight against cancer, certain anticancer remedies using herbs or herbal formulas derived from TCM have been developed for the management of malignancies. Furthermore, there are clinical trials registered for the use of herbal remedies in cancer management. Herbal medicine has been used as part of combined therapies to reduce the side-effects of chemotherapy, including bone marrow suppression, nausea and vomiting. Herbal remedies have also been used as chemopreventive therapies to treat precancerous conditions in order to reduce the incidence of cancer in high-risk populations. Emerging evidence has revealed that herbal remedies can regulate the proliferation, apoptosis, adhesion and migration of cancer cells. In addition to this direct effect upon cancer cells, a number of herbal remedies have been identified to suppress angiogenesis and therefore reduce tumour growth. The inhibition of tumour growth may also be due to modifications of the host immune system by the herbal treatment. However, the precise mechanisms underlying the therapeutic effects of herbal remedies remain poorly understood and are yet to be fully elucidated. The present study aims to summarize the current literature and clinical trial results of herbal remedies for cancer treatment, with a particular focus on the recent findings and development of the Yangzheng Xiaoji capsule.

Indexed as

cancermetastasistherapytraditional Chinese medicine

Identifiers

PMID26622657
PMCPMC4533180
OpenAlexW2160260402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.