ArticleOncology letters2015
JNK signaling pathway is involved in piperlongumine-mediated apoptosis in human colorectal cancer HCT116 cells.
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Article in Oncology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
3.2field-weighted citation impact, top 10% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Synthesis, anticancer evaluation, preliminary mechanism study of novel 1, 2, 3-triazole-piperlongumine derivatives.Molecular diversity · 2025Article
- Vernodalin Triggers ROS-Mediated Apoptosis in TPC-1 Human PapillaryThyroid Cancer CellsCombinatorial chemistry & high throughput screening · 2024Article
- Piperlongumine Induces Apoptosis and Cytoprotective Autophagy via the MAPK Signaling Pathway in Human Oral Cancer Cells.Biomedicines · 2023Article
- Article
- The promising potential of piperlongumine as an emerging therapeutics for cancer.Exploration of targeted anti-tumor therapy · 2021Review
- Natural Health Products (NHP's) and Natural Compounds as Therapeutic Agents for the Treatment of Cancer; Mechanisms of Anti-Cancer Activity of Natural Compounds and Overall Trends.International journal of molecular sciences · 2020Review
- Caffeine and its main targets of colorectal cancer.World journal of gastrointestinal oncology · 2020Review
- Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer.Frontiers in pharmacology · 2020Article
- JNK inhibition blocks piperlongumine-induced cell death and transcriptional activation of heme oxygenase-1 in pancreatic cancer cells.Apoptosis : an international journal on programmed cell death · 2019Article
- Novel piplartine-containing ruthenium complexes: synthesis, cell growth inhibition, apoptosis induction and ROS production on HCT116 cells.Oncotarget · 2017Article
- Effects of Hylomecon vernalis ethanol extracts on cell cycle and apoptosis of colon cancer cells.Molecular medicine reports · 2017Article
- Discovery of piperlongumine as a potential novel lead for the development of senolytic agents.Aging · 2016Article
- The role of MAPK signaling pathway in the Her-2-positive meningiomas.Oncology reports · 2016Article
- Transcriptome Analysis of Piperlongumine-Treated Human Pancreatic Cancer Cells Reveals Involvement of Oxidative Stress and Endoplasmic Reticulum Stress Pathways.Journal of medicinal food · 2016Article
- Dual-specificity Phosphatase 1 Deficiency Induces Endometrioid Adenocarcinoma Progression via Activation of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Pathway.Chinese medical journal · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Wen LiGuangdong Institute of Gastroenterology and The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China ; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China ; Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China ; Guangdong Provincial Key Laboratory of Allergy and Immunology, Guangzhou Medical University, Guangzhou, Guangdong 511436, P.R. China.
Chuangyu WenGuangdong Institute of Gastroenterology and The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China ; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China ; Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.
Haiyan BaiState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510080, P.R. China.
Xiaoyan WangGuangdong Institute of Gastroenterology and The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China ; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China ; Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.
Xiaoli ZhangGuangdong Institute of Gastroenterology and The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China.
Lanlan HuangGuangdong Institute of Gastroenterology and The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China ; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China ; Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.
Xiangling YangGuangdong Institute of Gastroenterology and The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China ; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China ; Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.
Aikichi IwamotoAdvanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
Huanliang LiuGuangdong Institute of Gastroenterology and The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China ; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China ; Institute of Human Virology, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.
Sixth Affiliated Hospital of Sun Yat-sen University · CNSun Yat-sen University · CNTokyo University of Science · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Piperlongumine (PPLGM), an alkaloid isolated from the long pepper (
Indexed as
apoptosisc-Jun NH2-terminal kinasescolorectal cancerphosphorylationpiperlongumineSP600125
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.