ArticleOncology letters2015
BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1.
Article in Oncology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- PC3/Tis21/BTG2 and BTG1 genes: regulators of the cell cycle and neurogenesis, as well as tumor suppressors in malignant brain tumors.Frontiers in cell and developmental biology · 2026Review
- Candidate biomarkers for treatment benefit from sunitinib in patients with advanced renal cell carcinoma using mass spectrometry-based (phospho)proteomics.Clinical proteomics · 2023Article
- Protein arginine methyltransferases in renal development, injury, repair, and fibrosis.Frontiers in pharmacology · 2023Review
- JMJD2C-mediated long non-coding RNA MALAT1/microRNA-503-5p/SEPT2 axis worsens non-small cell lung cancer.Cell death & disease · 2022Article
- The roles ofFrontiers in genetics · 2022Article
- Single Cell Transcriptomic Analyses Reveal the Impact of bHLH Factors on Human Retinal Organoid Development.Frontiers in cell and developmental biology · 2021Article
- Key Regulatory Differentially Expressed Genes in the Blood of Atrial Septal Defect Children Treated With Occlusion Devices.Frontiers in genetics · 2021Article
- Clinicopathological and prognostic impact of somatic mutations in Chinese patients with clear cell renal cell carcinoma.Translational andrology and urology · 2020Article
- PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance.Diagnostic pathology · 2019Article
- miR-27a-3p regulates proliferation and apoptosis of colon cancer cells by potentially targeting BTG1.Oncology letters · 2019Article
- Role of B-Cell Translocation Gene 1 in the Pathogenesis of Endometriosis.International journal of molecular sciences · 2019Article
- Identification of B-cell translocation gene 1-controlled gene networks in diffuse large B-cell lymphoma: A study based on bioinformatics analysis.Oncology letters · 2019Article
- Proteomic changes of CD4Experimental and therapeutic medicine · 2017Article
- miR-511 promotes the proliferation of human hepatoma cells by targeting the 3'UTR of B cell translocation gene 1 (BTG1) mRNA.Acta pharmacologica Sinica · 2017Article
- B-cell translocation gene 1 is downregulated by promoter methylation in ovarian carcinoma.Journal of Cancer · 2017Article
- MiR-4295 promotes cell growth in bladder cancer by targeting BTG1.American journal of translational research · 2016Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B-cell translocation gene 1 (BTG1) is a member of the BTG/transducer of Erb family. BTG1 regulates cell cycle progression, inhibits proliferation, promotes apoptosis and stimulates cellular differentiation in multiple cell types. However, the functions of BTG1 in renal cell carcinoma (RCC) remain unclear. Therefore, the present study investigated the role of BTG1 in RCC tissue samples and 786-O RCC cells. RCC tissues and cells exhibited significantly weaker BTG1 protein and mRNA expression compared with para-carcinoma control tissues (P<0.05). Upregulated BTG1 expression induced significant G0/G1 cell cycle arrest, apoptosis and inhibition of cell proliferation in 786-O cells (P<0.05). Furthermore, BTG1 interacted with protein arginine N-methyltransferase 1 (PRMT1), and blocking the action of PRMT1 in 786-O cells resulted in inhibition of BTG1 function. These findings indicate that BTG1 may inhibit cell growth and promote apoptosis by interacting with PRMT1 in RCC; the identification of this mechanism may aid in the production of novel therapies for RCC.
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