ArticleExperimental and therapeutic medicine2015
Association among the expression of β-catenin, cyclin D1 and estrogen receptor-β in human breast cancer.
Article in Experimental and therapeutic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF-7 cells.Experimental and therapeutic medicine · 2022Article
- Wnt/β-catenin signaling pathway in uterine leiomyoma: role in tumor biology and targeting opportunities.Molecular and cellular biochemistry · 2021Review
- Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/Case reports in pathology · 2021Article
- MicroRNA-216a suppresses the proliferation and migration of human breast cancer cells via the Wnt/β-catenin signaling pathway.Oncology reports · 2019Article
- Estrogen receptor subtype agonist activation in human cutaneous squamous cell carcinoma cells modulates expression of CD55 and Cyclin D1.EXCLI journal · 2019Article
- High-frequency deregulated expression of Wnt signaling pathway members in breast carcinomas.OncoTargets and therapy · 2018Article
- MicroRNA-520b affects the proliferation of human glioblastoma cells by directly targeting cyclin D1.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
β-catenin, cyclin D1 and estrogen receptor (ER)-β are closely associated with the pathogenesis of breast cancer. In the present study, tissue samples were collected from 226 patients with breast cancer. Subsequently, immunohistochemical analysis was performed to detect the expression of β-catenin, cyclin D1 and ER-β, and the Kaplan-Meier method was used for survival analysis. The abnormal expression rate of β-catenin was 75.2%, while the cyclin D1 positive expression rate was 77.0% and the ER-β positive expression rate was 43.4%. In the tissue samples exhibiting abnormal expression of β-catenin, the positive expression rate of cyclin D1 (85.9%) was significantly higher compared with the samples that expressed β-catenin normally (50.0%). Furthermore, the positive expression rate of ER-β (35.7%) in the β-catenin normal expression tissues was significantly lower compared with that in the β-catenin abnormal expression tissues (45.9%). In the tissues with positive cyclin D1 expression, the positive expression rate of ER-β (48.4%) was significantly higher compared with the cyclin D1 negative expression samples (26.9%). In addition, patients with normal expression of β-catenin and positive expression of cyclin D1 exhibited longer tumor-free survival times. Therefore, an association exists among the abnormal expression of β-catenin and the positive expression of cyclin D1 and ER-β, which may contribute to the development of breast cancer.
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