ArticleExperimental and therapeutic medicine2015
Construction of orthotopic xenograft mouse models for human pancreatic cancer.
Article in Experimental and therapeutic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Establishment of an orthotopic nude mouse model for recurrent pancreatic cancer after complete resection: an experimental animal study.Annals of surgical treatment and research · 2025Article
- Progress in building clinically relevant patient-derived tumor xenograft models for cancer research.Animal models and experimental medicine · 2023Review
- Dissecting metastasis using preclinical models and methods.Nature reviews. Cancer · 2023Review
- Article
- Orthotopic Models of Pancreatic Cancer to Study PDT.Methods in molecular biology (Clifton, N.J.) · 2022Article
- ImmunoPET/NIRF/Cerenkov multimodality imaging of ICAM-1 in pancreatic ductal adenocarcinoma.European journal of nuclear medicine and molecular imaging · 2021Article
- Pharmacokinetic-Pharmacodynamic Modeling of Tumor Targeted Drug Delivery Using Nano-Engineered Mesenchymal Stem Cells.Pharmaceutics · 2021Article
- In Vivo Flow Cytometric Evaluation of Circulating Metastatic Pancreatic Tumor Cells after High-Intensity Focused Ultrasound Therapy.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2020Article
- Modeling neoplastic disease with spheroids and organoids.Journal of hematology & oncology · 2020Review
- In Vivo Bioluminescence Tomography Center of Mass-Guided Conformal Irradiation.International journal of radiation oncology, biology, physics · 2020Article
- Review
- A Study Comparing the Effects of Targeted Intra-Arterial and Systemic Chemotherapy in an Orthotopic Mouse Model of Pancreatic Cancer.Scientific reports · 2019Article
- Xenograft and organoid model systems in cancer research.The EMBO journal · 2019Review
- Development of orthotopic tumour models using ultrasound-guided intrahepatic injection.Scientific reports · 2019Article
- Radiosensitivity of Cancer Cells Is Regulated by Translationally Controlled Tumor Protein.Cancers · 2019Article
- Article
- Article
- Difference in morphology and interactome profiles between orthotopic and subcutaneous gastric cancer xenograft models.Journal of toxicologic pathology · 2018Article
- iRGD-functionalized PEGylated nanoparticles for enhanced colon tumor accumulation and targeted drug delivery.Nanomedicine (London, England) · 2017Article
- Interrogating open issues in cancer precision medicine with patient-derived xenografts.Nature reviews. Cancer · 2017Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal models are indispensable for the study of tumorigenesis and the development of anti-cancer drugs for human pancreatic cancer. In the present study, two orthotopic xenograft mouse models were developed. AsPC-1 human pancreatic cancer cells were stably labeled with red fluorescent protein (RFP) and injected subcutaneously into nude mice. For the orthotopic tumor mass model, the formed subcutaneous tumors were cut into blocks and implanted into the pancreas of nude mice via laparotomy. For the Matrigel™ tumor block model, solidified Matrigel containing RFP-labeled AsPC-1 cells was cut into blocks and implanted into the pancreas of nude mice. A subcutaneous tumor xenograft model was used as a control. Tumor growth and metastasis were assessed using an
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.