ArticleExperimental and therapeutic medicine2015
Combination of vascular endothelial growth factor-loaded microspheres and hyperbaric oxygen on random skin flap survival in rats.
Article in Experimental and therapeutic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- The application of SFDI and LSI system to evaluate the blood perfusion in skin flap mouse model.Lasers in medical science · 2022Article
- Pressure-driven spreadable deferoxamine-laden hydrogels for vascularized skin flaps.Biomaterials science · 2021Article
- Chemically Modified SDF-1α mRNA Promotes Random Flap Survival by Activating the SDF-1α/CXCR4 Axis in Rats.Frontiers in cell and developmental biology · 2021Article
- Expression and Significance of MicroRNA155 in Serum of Patients with Cerebral Small Vessel Disease.Journal of Korean Neurosurgical Society · 2020Article
- Detrimental Effect of Sitagliptin Induced Autophagy on Multiterritory Perforator Flap Survival.Frontiers in pharmacology · 2020Article
- FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.Cell death & disease · 2019Article
- Effects of bradykinin on the survival of multiterritory perforator flaps in rats.World journal of surgical oncology · 2019Article
- Use of Biologically Active 3D Matrix for Extensive Skin Defect Treatment in Veterinary Practice: Case Report.Frontiers in veterinary science · 2019Article
- Hyperbaric oxygen therapy in the treatment of complications of irradiation in laryngeal cancer.Contemporary oncology (Poznan, Poland) · 2018Article
- Detrimental effect of Hypoxia-inducible factor-1α-induced autophagy on multiterritory perforator flap survival in rats.Scientific reports · 2017Article
- Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to investigate the role of hyperbaric oxygen (HBO) and treatment with vascular endothelial growth factor (VEGF)-loaded microspheres, and HBO plus VEGF on the survival of random skin flaps in rats. The modified McFarlane flap model was established in 40 rats and evaluated within four groups: VEGF (n=10), HBO (n=10), HBO plus VEGF (n=10) and controls (n=10). Seven days following treatment, the necrotic area of the flap was measured. The specimens were stained with hematoxylin and eosin for histological analysis. Immunohistochemical staining was used to analyze the positive expression levels of VEGF. The percentages of necrosis of the skin flaps in all groups were: 49.66±2.64% in controls, 26.85±1.77% in VEGF, 28.27±2.21% in HBO and 10.44±2.48% in the combination group. Histological analysis demonstrated angiogenesis with mean vessel density per mm
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.