Evidence map›Paper›PMID 26622350›Full record

ArticleExperimental and therapeutic medicine2015

Effects of IgG anti-GM1 monoclonal antibodies on neuromuscular transmission and calcium channel binding in rat neuromuscular junctions.

Sayako Hotta, Yoshihiko Nakatani, Toshie Kambe, Kenji Abe, Yutaka Masuda, Iku Utsumomiya, Kyoji Taguchi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sayako HottaDepartment of Medicinal Pharmacology, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan.
Yoshihiko NakataniDepartment of Medicinal Pharmacology, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan.
Toshie KambeDepartment of Pharmacology, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan.
Kenji AbeDepartment of Pharmacology, School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima 963-8611, Japan.
Yutaka MasudaLaboratory of Clinical Pharmacy, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan.
Iku UtsumomiyaDepartment of Developmental Education, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan.
Kyoji TaguchiDepartment of Medicinal Pharmacology, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan.
Showa Pharmaceutical University · JPOhu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guillain-Barré syndrome is a type of acute inflammatory neuropathy that causes ataxia and is associated with the IgG anti-GM1 antibody. However, the pathogenic role of the IgG anti-GM1 antibody and calcium channels in neuromuscular junctions (NMJs) remains unclear. Thus, the aim of the present study was to investigate the effects of the IgG anti-GM1 monoclonal antibody (mAb) on spontaneous muscle action potentials (SMAPs), and the effects of calcium channel blockers, in a rat spinal cord-muscle co-culture system. In addition, the binding of IgG anti-GM1 mAb to calcium channels was investigated in the rat hemidiaphragm. The frequency of SMAPs in the innervated muscle cells was acutely inhibited by the IgG anti-GM1 mAb; however, this effect was blocked by the N-type calcium channel blocker, ω-conotoxin GVIA (30 nM). Furthermore, the P/Q-type calcium channel blocker, ω-agatoxin IVA (10 nM), was found to partially block the IgG anti-GM1 mAb-induced inhibitory effect in the spinal cord-muscle co-culture system. Immunohistochemical analysis of the rat hemidiaphragm indicated that IgG anti-GM1 mAb binding overlapped with anti-Ca

Indexed as

calcium channelGuillain-Barré syndromeIgG anti-GM1 monoclonal antibodymuscle action potentialneuromuscular junctions

Identifiers

PMID26622350
PMCPMC4509117
OpenAlexW1559334790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.