ArticleIranian journal of parasitology
Influence of Toxoplasma gondii Infection on Male Fertility: A Pilot Study on Immunocompetent Human Volunteers.
Article in Iranian journal of parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Toxoplasma gondii Infection in the Male Reproductive System: A Systematic Review.Acta parasitologica · 2025Pooled it
- Toxoplasma gondii infection and testosterone alteration: A systematic review and meta-analyses.PloS one · 2024Pooled it
- Chronic Toxoplasma gondii infection and its influence on semen analysis in rats: controlled experimental animal study.Scientific reports · 2026Article
- Review
- Differential transcriptome study on the damage of testicular tissues caused by chronic infection of T. gondii in mice.Parasites & vectors · 2024Article
- Microbiology and immune mechanisms associated with male infertility.Frontiers in immunology · 2023Review
- Associations betweenInternational journal for parasitology. Parasites and wildlife · 2022Article
- Transcriptome Analysis of Testes and Uterus: Reproductive Dysfunction Induced byMicroorganisms · 2020Article
- Curcumin as an indirect methylation inhibitor modulates the effects ofEXCLI journal · 2020Article
- Transcriptomic analysis of reproductive damage in the epididymis of male Kunming mice induced by chronic infection of Toxoplasma gondii PRU strain.Parasites & vectors · 2019Article
- Testicular toxoplasmosis in a 26-year-old immunocompetent man.BMJ case reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study was conducted to investigate the influence of Toxoplasma gondii infection on spermatic and hormonal parameters in a pilot sample of immunocompetent human male subjects.
methodsThis cross sectional, observational pilot study on 60 immunocompetent human male subjects aged between 18 and 60 yr old was conducted between 2012 -2013. Blind evaluation of serological markers of past T. gondii infection (TOX-IgG, TOX-IgM) was performed, along with individual spermiograms and determinations of follicle-stimulating hormone (FSH) and testosterone serum levels.
resultsThe overall prevalence of past T. gondii infection in the investigated immunocompetent male subjects was 25%. No statistically significant influence of T. gondii infection on sperm characteristics (ejaculate quantity, sperm count, motility, morphology) and serum levels of FSH or testosterone were found. Among possible predictors of a modified spermiogram studied by multiple logistic regression along with the T. gondii infection (age, smoking, alcohol consumption, fertility influencing malformations, infections, trauma or medication), only the presence of varicocele in the medical history of the studied subjects was found to significantly participate in the prediction of a modified spermiogram (P=0.0154). A necessary sample size of 994 subjects was computed in order to achieve a test power of 0.8 (80%) to discriminate an effect size of 8.89% estimated by our pilot study.
conclusionsAlthough our investigation did not demonstrate an influence of latent T. gondii infection on spermatic and hormonal parameters of immunocompetent male humans, the absence of such an influence cannot be affirmed, due to the limited sample size of our pilot study.
Indexed as
Identifiers
26622295PMC4662740W2195301749What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.