ArticleIranian journal of parasitology
Interleukin-18 Antagonism Improved Histopathological Conditions of Malaria Infection in Mice.
Article in Iranian journal of parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Immunomodulatory Effects ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Promising Anti-Protozoan Activities of Propolis (Bee Glue) as Natural Product: A Review.Acta parasitologica · 2021Review
- Resveratrol Protects against Restraint Stress Effects on Stomach and Spleen in Adult Male Mice.Animals : an open access journal from MDPI · 2019Article
- Protective vaccination alters gene expression of the liver of Balb/c mice in response to early prepatent blood-stage malaria of Plasmodium chabaudi.Parasitology research · 2018Article
- In vivo assessment of the antimalarial and spleen-protective activities of the Saudi propolis methanolic extract.Parasitology research · 2017Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterleukin 18 (IL-18) exerts pleiotropic roles in many inflammatory-related diseases including parasitic infection. Previous studies have demonstrated the promising therapeutic potential of modulating IL-18 bioactivity in various pathological conditions. However, its involvement during malaria infection has yet to be established. In this study, we demonstrated the effect of modulating IL-18 on the histopathological conditions of malaria infected mice.
methodsPlasmodium berghei ANKA infection in male ICR mice was used as a model for malaria infection. Modulation of IL-18 release was carried out by treatment of malarial mice with recombinant mouse IL-18 (rmIL-18) and recombinant mouse IL-18 Fc chimera (rmIL-18Fc) intravenously. Histopathological study and analysis were performed on major organs including brain, liver, spleen, lungs and kidney.
resultsTreatment with rmIL-18Fc resulted in significant improvements on the histopathological conditions of the organs in malaria-infected mice.
conclusionIL-18 is an important mediator of malaria pathogenesis and targeting IL-18 could prove beneficial in malaria-infected host.
Indexed as
Identifiers
26622294PMC4662739W2221896192What OpenQuestion holds
Registered trials
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