ArticleInternational journal of trichology
Involvement of Mechanical Stress in Androgenetic Alopecia.
Article in International journal of trichology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Use of Botulinum Toxin for Androgenic Alopecia: A Systematic Review.Skin appendage disorders · 2022Pooled it
- Efficacy of type A botulinum toxin treatment for androgenetic alopecia using ultrasound combined with trichoscopy.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Trial
- Novel Combination Scalp Therapy for Androgenetic Alopecia: A Preliminary Retrospective Case Series with an Illustrative Four-Year Case.Journal of clinical medicine · 2026Article
- High-frequency ultrasonography of the scalp: A comparison between androgenetic alopecia and healthy volunteers.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Postpartum Telogen Effluvium Unmasking Additional Latent Hair Loss Disorders.The Journal of clinical and aesthetic dermatology · 2024Article
- Androgenetic Alopecia Among Hospital Staff: A Study of Prevalence, Types and a Comparison with General Population in a Secondary Hospital in China.Clinical, cosmetic and investigational dermatology · 2021Article
- Self-Assessments of Standardized Scalp Massages for Androgenic Alopecia: Survey Results.Dermatology and therapy · 2019Article
- Exogen Hairs in Women with and without Hair Loss.Skin appendage disorders · 2017Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAndrogenetic alopecia (AGA) is a frequent disorder characterized by progressive hair miniaturization in a very similar pattern among all affected men. The pathogenesis is related to androgen-inducible overexpression of transforming growth factor β-1 from balding dermal papilla cells, which is involved in epithelial inhibition and perifollicular fibrosis. Recent research shows that hair follicle androgen sensitivity is regulated by Hic-5, an androgen receptor co-activator which may be activated by the mechanical stimulation. Moreover, the dermis of scalp susceptible to be affected by AGA is firmly bounded to the galea aponeurotica, so the physical force exerted by the occipitofrontalis muscle is transmitted to the scalp skin.
aimsTo know whether mechanical stress supported by hair follicles is involved in AGA phenomenon. MATERIALS AND
methodsIt is performed with a finite element analysis of a galea model and a schematic representation of AGA progression according to Hamilton-Norwood scale in order to establish the correlation between elastic deformation in scalp and clinical progression of male pattern baldness.
resultsThe result was a highly significant correlation (r: -0.885, P < 0.001) that clearly identifies a mechanical factor in AGA development.
conclusionsAll these data suggest that mechanical stress determines AGA patterning and a stretch-induced and androgen-mediated mechanotransduction in dermal papilla cells could be the primary mechanism in AGA pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.