ReviewEuropean respiratory review : an official journal of the European Respiratory Society2015
Pulmonary arterial hypertension: the burden of disease and impact on quality of life.
Review in European respiratory review : an official journal of the European Respiratory Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
116 citing papers in PubMed, 5 syntheses or guidelines pooled it, 181 citations in OpenAlex.
- Effects of different exercise-based rehabilitation programs in adults with pulmonary arterial hypertension and related pulmonary hypertension populations: a systematic review and network meta-analysis.BMC sports science, medicine & rehabilitation · 2026Pooled it
- Quality of life in patients with pulmonary arterial hypertension: A systematic review and meta-analysis.Health and quality of life outcomes · 2026Pooled it
- Adults' experiences of living with pulmonary hypertension: a thematic synthesis of qualitative studies.BMJ open · 2020Pooled it
- Systematic Review of Health-Related Quality of Life in Patients with Pulmonary Arterial Hypertension.PharmacoEconomics · 2016Pooled it
- Efficacy of Statin Therapy in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis.Scientific reports · 2016Pooled it
- Trial
- Individually tailored home-based physiotherapy program makes sustainable improvement in exercise capacity and daily physical activity in patients with pulmonary arterial hypertension.Therapeutic advances in respiratory diseaseTrial
- Patient Perceptions of a Video-Based Educational Platform for Pulmonary Arterial Hypertension: A Qualitative Study of the SMART-PAH Course.Pulmonary circulation · 2026Article
- Effect of Incident Pulmonary Arterial Hypertension on Risk of Newly-Diagnosed Mental Health Conditions.Pulmonary circulation · 2026Article
- Shared Decision-Making During Pulmonary Arterial Hypertension Therapy Selection: A Patient and Clinician Survey.Pulmonary circulation · 2026Article
- Patient Perspectives on Palliative Care in Pulmonary Arterial Hypertension in the United States.Pulmonary circulation · 2026Article
- A Randomized Controlled Trial of Specialty Palliative Care to Improve Health-Related Quality of Life in Pulmonary Arterial Hypertension.Pulmonary circulation · 2026Article
- Understanding the burden of pulmonary arterial hypertension among patients and caregivers through narrative medicine: data from Italian multicentre observational INSPECTIO study.BMJ open respiratory research · 2026Observational
- Quality of life and associated factors among people living with hypertension in a tertiary hospital of Kathmandu District, Nepal.BMC cardiovascular disorders · 2026Article
- Article
- Perfusion-only Q-SPECT as a rule-out tool for CTEPH in resource-limited settings: a feasibility study on reducing unnecessary referrals to tertiary centers.BMC pulmonary medicine · 2026Article
- The Pulmonary Hypertension Global Patient Survey: Groups 2 and 3.Pulmonary circulation · 2026Article
- Reliability and validity of the Turkish version of the Barthel Index-dyspnea in patients with pulmonary hypertension.Turkish journal of medical sciences · 2026Article
- SARS-CoV-2 infection and two-year longitudinal clinical trajectory in pulmonary hypertension: a single-center retrospective exploratory cohort study.Frontiers in public health · 2026Article
- The Pulmonary Hypertension Global Patient Survey: Physical and Psychosocial Impacts on Health-Related Quality of Life.Pulmonary circulation · 2026Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary arterial hypertension (PAH) is a debilitating disease that pervades all aspects of a patient's daily life. It is also increasingly acknowledged that the burden of PAH extends to older patients and carers. Until recently, the adverse effect of disease symptoms on the physical, emotional and social factors governing patient health-related quality of life (HRQoL) remained largely unrecognised. With a shift in therapeutic objectives to longer term improvements and HRQoL benefits, clinical trials now frequently include HRQoL measures as study end-points. Most HRQoL instruments used in patients with PAH are generic or non-disease-specific questionnaires and therefore may not accurately capture PAH disease burden. New PAH-specific HRQoL instruments currently undergoing validation include emPHasis-10 and Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT; Actelion Pharmaceuticals Ltd, Allschwil, Switzerland). Using various HRQoL measures, pharmacological therapies have been shown to improve HRQoL in patients with PAH. Patients also derive HRQoL benefits from nonpharmacological strategies, which include the emotional support provided by multidisciplinary care and support groups that is fundamental to patient wellbeing. Looking to the future, validated PAH-specific HRQoL instruments together with dedicated guidelines and procedures are essential to support the translation of HRQoL scores to the clinic, thus enabling a holistic treatment approach to the management of patients with PAH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.