ReviewClinical science (London, England : 1979)2016
Sex, the brain and hypertension: brain oestrogen receptors and high blood pressure risk factors.
Review in Clinical science (London, England : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Clinical practice guideline of the Interamerican Society of Cardiology on primary prevention of cardiovascular disease in women.Archivos de cardiologia de Mexico · 2022Guideline
- Adverse Childhood Experiences and Blood Pressure in Women in the United States: A Systematic Review.Journal of midwifery & women's health · 2021Pooled it
- Female sex hormones do not drive the sex-specific mechanisms of obesity-related hypertension.American journal of physiology. Heart and circulatory physiology · 2025Article
- Age, Sex, and Central Adiposity as Determinants of Autonomic Nervous System Reactivity in Adults.Medicina (Kaunas, Lithuania) · 2025Article
- Causal associations between hypertension and abnormal brain cortical structures: Insights from a bidirectional Mendelian randomization study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Cortical-brainstem circuitry attenuates physiological stress reactivity.The Journal of physiology · 2024Article
- Hindbrain Adrenergic/Noradrenergic Control of Integrated Endocrine and Autonomic Stress Responses.Endocrinology · 2023Review
- Association between atherogenic index of plasma and prehypertension or hypertension among normoglycemia subjects in a Japan population: a cross-sectional study.Lipids in health and disease · 2023Article
- A serotonin-deficient rat model of neurogenic hypertension: influence of sex and sympathetic vascular tone.Journal of neurophysiology · 2022Article
- Sex-Specific Trends in the Prevalence of Hypertension and the Number of People With Hypertension: Analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 1998-2018.Korean circulation journal · 2022Article
- Association between comorbidity and health-related quality of life in a hypertensive population: a hospital-based study in Bangladesh.BMC public health · 2022Article
- Sex-dependent development of enhanced sympathoexcitation in sedentary versus physically active rats.The Journal of physiology · 2021Article
- Determinants of change in blood pressure in Ghana: Longitudinal data from WHO-SAGE Waves 1-3.PloS one · 2021Article
- Hypertension and Age-Related Cognitive Impairment: Common Risk Factors and a Role for Precision Aging.Current hypertension reports · 2020Review
- Sex differences in solute transport along the nephrons: effects of NaAmerican journal of physiology. Renal physiology · 2020Article
- Sex-steroid-dependent plasticity of brain-stem autonomic circuits.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Review
- Obesity: sex and sympathetics.Biology of sex differences · 2020Review
- Activation of bradykinin-sensitive pericardial afferents increases systemic venous tone in conscious rats.Autonomic neuroscience : basic & clinical · 2020Article
- Health-related quality of life among patients with hypertension: population-based survey using EQ-5D-5L in Hong Kong SAR, China.BMJ open · 2019Article
- Leptin and Aldosterone.Vitamins and hormones · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Hypertension is a major contributor to worldwide morbidity and mortality rates related to cardiovascular disease. There are important sex differences in the onset and rate of hypertension in humans. Compared with age-matched men, premenopausal women are less likely to develop hypertension. However, after age 60, the incidence of hypertension increases in women and even surpasses that seen in older men. It is thought that changes in levels of circulating ovarian hormones as women age may be involved in the increase in hypertension in older women. One of the key mechanisms involved in the development of hypertension in both men and women is an increase in sympathetic nerve activity (SNA). Brain regions important for the regulation of SNA, such as the subfornical organ, the paraventricular nucleus and the rostral ventral lateral medulla, also express specific subtypes of oestrogen receptors. Each of these brain regions has also been implicated in mechanisms underlying risk factors for hypertension such as obesity, stress and inflammation. The present review brings together evidence that links actions of oestrogen at these receptors to modulate some of the common brain mechanisms involved in the ability of hypertensive risk factors to increase SNA and blood pressure. Understanding the mechanisms by which oestrogen acts at key sites in the brain for the regulation of SNA is important for the development of novel, sex-specific therapies for treating hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.