Evidence map›Paper›PMID 26621834›Full record

ArticleOncotarget2015

Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals.

Zhenwei Shang, Hongchao Lv, Mingming Zhang, Lian Duan, Situo Wang, Jin Li, Guiyou Liu, Zhang Ruijie, Yongshuai Jiang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 46 citations in OpenAlex.

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  14. Journal of Cancer · 2019
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  18. Fragility Extraordinaire: Unsolved Mysteries of Chromosome Fragile Sites.Advances in experimental medicine and biology · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zhenwei ShangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Hongchao LvCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Mingming ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Lian DuanCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Situo WangGenetic Data Analysis Group, The Genome Science Consortium, Harbin, China.
Jin LiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Guiyou LiuGenome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Zhang RuijieCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Yongshuai JiangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Harbin Medical University · CNTianjin Institute of Industrial Biotechnology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is an acquired disorder of cognitive and behavioral impairment. It is considered to be caused by variety of factors, such as age, environment and genetic factors. In order to identify the genetic affect factors of AD, we carried out a bioinformatic approach which combined genome-wide haplotype-based association study with gene prioritization. The raw SNP genotypes data was downloaded from GEO database (GSE33528). It contains 615 AD patients and 560 controls of Caribbean Hispanic individuals. Firstly, we identified the linkage disequilibrium (LD) haplotype blocks and performed genome-wide haplotype association study to screen significant haplotypes that were associated with AD. Then we mapped these significant haplotypes to genes and obtained candidate genes set for AD. At last, we prioritized AD candidate genes based on their similarity with 36 known AD genes, so as to identify AD related genes. The results showed that 141 haplotypes on 134 LD blocks were significantly associated with AD (P<1E-4), and these significant haplotypes were mapped to 132 AD candidate genes. After prioritizing these candidate genes, we found seven AD related genes: APOE, APOC1, TNFRSF1A, LRP1B, CDH1, TG and CASP7. Among these genes, APOE and APOC1 are known AD risk genes. For the other five genes TNFRSF1A, CDH1, CASP7, LRP1B and TG, this is the first genetic association study which showed the significant association between these five genes and AD susceptibility in Caribbean Hispanic individuals. We believe that our findings can provide a new perspective to understand the genetic affect factors of AD.

Indexed as

Alzheimer DiseaseAntigens, CDCadherinsCaribbean RegionCaspase 7Genetic Predisposition to DiseaseGenome-Wide Association StudyHaplotypesHispanic or LatinoHumansLinkage DisequilibriumMicrofilament ProteinsMuscle ProteinsPolymorphism, Single NucleotideReceptors, LDLReceptors, Tumor Necrosis Factor, Type IAntigens, CDCadherinsCASP7 protein, humanCaspase 7CDH1 protein, humanLRP1B protein, humanMicrofilament ProteinsMuscle ProteinsReceptors, LDLReceptors, Tumor Necrosis Factor, Type ITNFRSF1A protein, humantransgelinAlzheimer’s diseasehaplotype association analysisPathology Section

Identifiers

PMID26621834
PMCPMC4767448
OpenAlexW2174832892

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.