ArticleBiology open2015
Analysis of neural progenitors from embryogenesis to juvenile adult in Xenopus laevis reveals biphasic neurogenesis and continuous lengthening of the cell cycle.
Article in Biology open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
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- Adeno-associated viral tools to trace neural development and connectivity across amphibians.Developmental cell · 2025Article
- Spinal neuron diversity scales exponentially with swim-to-limb transformation during frog metamorphosis.bioRxiv : the preprint server for biology · 2024Article
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- β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the DevelopingInternational journal of molecular sciences · 2023Article
- Article
- Temporal and spatial transcriptomic dynamics across brain development in Xenopus laevis tadpoles.G3 (Bethesda, Md.) · 2022Article
- Foxm1 regulates neural progenitor fate during spinal cord regeneration.EMBO reports · 2021Article
- A systemic cell cycle block impacts stage-specific histone modification profiles during Xenopus embryogenesis.PLoS biology · 2021Article
- Cellular response to spinal cord injury in regenerative and non-regenerative stages in Xenopus laevis.Neural development · 2021Article
- Xenopus leads the way: Frogs as a pioneering model to understand the human brain.Genesis (New York, N.Y. : 2000) · 2021Review
- Nutrient restriction causes reversible G2 arrest inDevelopment (Cambridge, England) · 2019Article
- RNA helicase Mov10 is essential for gastrulation and central nervous system development.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Pattern of Neurogenesis and Identification of Neuronal Progenitor Subtypes during Pallial Development inFrontiers in neuroanatomy · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Xenopus laevis is a prominent model system for studying neural development, but our understanding of the long-term temporal dynamics of neurogenesis remains incomplete. Here, we present the first continuous description of neurogenesis in X. laevis, covering the entire period of development from the specification of neural ectoderm during gastrulation to juvenile frog. We have used molecular markers to identify progenitors and neurons, short-term bromodeoxyuridine (BrdU) incorporation to map the generation of newborn neurons and dual pulse S-phase labelling to characterise changes in their cell cycle length. Our study revealed the persistence of Sox3-positive progenitor cells from the earliest stages of neural development through to the juvenile adult. Two periods of intense neuronal generation were observed, confirming the existence of primary and secondary waves of neurogenesis, punctuated by a period of quiescence before metamorphosis and culminating in another period of quiescence in the young adult. Analysis of multiple parameters indicates that neural progenitors alternate between global phases of differentiation and amplification and that, regardless of their behaviour, their cell cycle lengthens monotonically during development, at least at the population level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.