Evidence map›Paper›PMID 26621817›Full record

SynthesisScientific reports2015

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

Timothy H T Cheng, Deborah Thompson, Jodie Painter, Tracy O'Mara, Maggie Gorman, Lynn Martin, Claire Palles, Angela Jones, Daniel D Buchanan, Aung Ko Win and 91 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Review
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  10. Control ofFrontiers in immunology · 2023
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  12. Review
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  14. The mRNA-bound Proteome ofMolecular & cellular proteomics : MCP · 2019
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Identification of Pleiotropic Cancer Susceptibility Variants from Genome-Wide Association Studies Reveals Functional Characteristics.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

101 authors at 20 institutions in 15 countries.

Timothy H T ChengMolecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Deborah ThompsonCentre for Cancer Genetic Epidemiology, Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Jodie PainterThe Molecular Cancer Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
Tracy O'MaraThe Molecular Cancer Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
Maggie GormanMolecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Lynn MartinMolecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Claire PallesMolecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Angela JonesMolecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Daniel D BuchananOncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Victoria, Australia.
Aung Ko WinCentre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, Australia.
John HopperCentre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, Australia.
Mark JenkinsCentre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, Australia.
Noralane M LindorDepartment of Health Sciences Research, Mayo Clinic, Scottsdale, AZ, USA.
Polly A NewcombCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Steve GallingerLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
David ContiDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Fred SchumacherDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Graham CaseyDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Graham G GilesCentre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, Australia.
Paul PharoahCentre for Cancer Genetic Epidemiology, Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Julian PetoLondon School of Hygiene and Tropical Medicine, London, UK.
Angela CoxSheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK.
Anthony SwerdlowDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK and 17 Division of Breast Cancer Research, Institute of Cancer Research, London, UK.
Fergus CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Julie M CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Ellen L GoodeDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Stacey J WinhamDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Diether LambrechtsDepartment of Oncology, KU Leuven, Belgium.
Peter FaschingUniversity of California at Los Angeles, Department of Medicine, Division of Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA, USA.
Barbara BurwinkelDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Hermann BrennerDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology Stuttgart, University of Tuebingen, Germany.
Hiltrud BrauchDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology Stuttgart, University of Tuebingen, Germany.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Helga B SalvesenDepartment of Clinical Science, Center for Cancer Biomarkers, University of Bergen, Norway.
Vessela KristensenDepartment of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway; The K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Clinical Molecular Oncology, Division of Medicine, Akershus University Hospital, Ahus, Norway.
Hatef DarabiDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Jingmei LiDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Tao LiuDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Magdalena Echeverry de PolancoGrupo de investigación Citogenética, Filogenia y Evolución de Poblaciones, Universidad del Tolima, Ibagué, Tolima, Colombia.
Monica SansDepartamento de Antropologia Biologica, Facultad de Humanidades, UDELAR, Magallanes 1577, CP 11200, Montevideo, Uruguay.
Angel CarracedoUniversidade de Santiago de Compostel, R/ San Francisco s/n 15782, Santiago de Compostela, Spain.
Sergi Castellvi-BelGenetic Predisposition to Colorectal Cancer Group, Gastrointestinal &Pancreatic Oncology Team, IDIBAPS/CIBERehd/Hospital Clínic, Centre Esther Koplowitz (CEK), Rosselló 153 planta 4, 08036 Barcelona, Spain.
Augusto Rojas-MartinezUniversidad Autónoma De Nuevo León, Pedro de Alba s/n, San Nicolás de Los Garza, Nuevo León, Mexico.
Samuel Aguiar JnrHospital A.C. Camargo, São Paulo, Brazil.
Manuel R TeixeiraDepartment of Genetics and IPO-Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal, and Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Joe DennisCentre for Cancer Genetic Epidemiology, Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Geoffrey OttonSchool of Medicine and Public Health, University of Newcastle, NSW, Australia.
Tony ProiettoSchool of Medicine and Public Health, University of Newcastle, NSW, Australia.
Elizabeth HollidayHunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia.
John AttiaHunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia.
Katie AshtonHunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia.
Rodney J ScottHunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia.
Mark McEvoyCentre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, NSW, Australia.
Sean C DowdyDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mayo Clinic, Rochester, MN, USA.
Brooke L FridleyDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA.
Henrica M J WernerCentre for Cancer Biomarkers, Department of Clinical Science, The University of Bergen, Norway.
Jone TrovikCentre for Cancer Biomarkers, Department of Clinical Science, The University of Bergen, Norway.
Tormund S NjolstadCentre for Cancer Biomarkers, Department of Clinical Science, The University of Bergen, Norway.
Emma ThamDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Miriam MintsDepartment of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Ingo RunnebaumDepartment of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.
Peter HillemannsHannover Medical School, Clinics of Gynaecology and Obstetrics, Hannover, Germany.
Thilo DörkHannover Medical School, Gynaecology Research Unit, Hannover, Germany.
Frederic AmantDivision of Gynaecological Oncology, University Hospital Leuven, Leuven, Belgium.
Stefanie SchrauwenDepartment of Oncology, KU Leuven, Belgium.
Alexander HeinDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Arif EkiciInstitute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Alfons MeindlDepartment of Obstetrics and Gynecology, Division of Tumor Genetics, Technical University of Munich, Munich, Germany.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Jonathan P TyrerCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Qin WangCentre for Cancer Genetic Epidemiology, Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Shahana AhmedCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Catherine S HealeyCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Mitul ShahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Daniela AnnibaliDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals, KU Leuven, University of Leuven, 3000, Belgium.
Jeroen DepreeuwDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals, KU Leuven, University of Leuven, 3000, Belgium.
Nada A Al-TassanDepartment of Genetics, King Faisal Specialist Hospital and Research Center, P.O.Box 3354, Riyadh11211, Saudi Arabia.
Rebecca HarrisInstitute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
Brian F MeyerDepartment of Genetics, King Faisal Specialist Hospital and Research Center, P.O.Box 3354, Riyadh11211, Saudi Arabia.
Nicola WhiffinDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
Fay J HoskingDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
Ben KinnersleyDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
Susan M FarringtonColon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
Maria TimofeevaColon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
Albert TenesaThe Roslin Institute, University of Edinburgh, Easter Bush, Roslin, EH25 9RG, UK.
Harry CampbellCentre for Population Health Sciences, University of Edinburgh, Edinburgh, EH8 9AG, UK.
Robert W HaileStanford Cancer Institute, Lorry Lokey Building/SIM 1, 265 Campus Drive, Ste G2103, Stanford, CA 94305-5456, USA.
Shirley HodgsonDepartment of Cancer Genetics, St. George's University of London, London SW17 0RE, UK.
Luis Carvajal-CarmonaGenome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, USA.
Jeremy P CheadleInstitute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.
Douglas EastonCentre for Cancer Genetic Epidemiology, Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Malcolm DunlopColon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
Richard HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
Amanda SpurdleThe Molecular Cancer Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
Ian TomlinsonMolecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Karolinska Institutet · SEUniversity of Cambridge · GBCancer Research UK Cambridge Center · GBInstitute of Cancer Research · GBKU Leuven · BEMayo Clinic in Arizona · USUniversity of Bergen · NOUniversity of Edinburgh · GBUniversity of Melbourne · AUUniversity of Oxford · GBHeidelberg University · DEHunter Medical Research Institute · AUQIMR Berghofer Medical Research Institute · AUUniversity of Newcastle Australia · AUUniversity of Southern California · USCardiff University · GBCentre for Human Genetics · GBKing Faisal Specialist Hospital & Research Centre · SAMayo Clinic in Florida · USMedizinische Hochschule Hannover · DE

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
USC Consortium:Colorectal Cancer Family RegistryU01CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 1997 to 2008
$20.4M
Data sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8M
SEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1M
ONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCERU01CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 1997 to 2008
$12.5M
Colon Cancer Family Registry CohortUM1CA167551 · NCI · STANFORD UNIVERSITY · PI HAILE, ROBERT WILLIAM, JENKINS, MARK A · 2013 to 2017
$11.3M
FAMILIAL COLORECTAL NEOPLASIA COLLABORATIVE GROUPU01CA074800 · NCI · MAYO CLINIC ROCHESTER · PI LINDOR, NORALANE MOREY · 1997 to 2007
$9.1M
Inherited colorectal cancer risk variants: from association to biologyR01CA143237 · NCI · UNIVERSITY OF VIRGINIA · PI CASEY, GRAHAM · 2010 to 2020
$8.4M
The Colon Cancer Family Registry: USC ConsortiumU24CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 2008 to 2011
$7.6M
Genomic Wide Association Study of Colorectal CancerU01CA122839 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CASEY, GRAHAM · 2006 to 2010
$7.3M
The Colon Cancer Family Registry: SeattleU24CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 2008 to 2011
$7.0M
AUSTRALASIAN COLORECTAL CANCER FAMILY REGISTRYU01CA097735 · NCI · UNIVERSITY OF MELBOURNE · PI HOPPER, JOHN L · 2002 to 2007
$6.9M
Cancer Research UK 10124Cancer Research UK 12076Cancer Research UK 13154Cancer Research UK 16459Cancer Research UK 16561Cancer Research UK 16563Cancer Research UK 16565Medical Research Council G1001799Medical Research Council MC_PC_U127527198Medical Research Council MC_U127527198Medical Research Council MR/K014781/1Medical Research Council MR/K018647/1Medical Research Council MR/N01104X/1NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA143237NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA074799NCI NIH HHS U01 CA074800NCI NIH HHS U01 CA074806NCI NIH HHS U01 CA097735NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA167551NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA074799NCI NIH HHS U24 CA074800NCI NIH HHS U24 CA074806NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167551Wellcome TrustWellcome Trust 090532/Z/09/Z
6 · The paper itself

Abstract

High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using CRC and EC genome-wide association series, totalling 13,265 cancer cases and 40,245 controls, we found that the protective allele [G] at one previously-identified CRC polymorphism, rs2736100 near TERT, was associated with EC risk (odds ratio (OR) = 1.08, P = 0.000167); this polymorphism influences the risk of several other cancers. A further CRC polymorphism near TERC also showed evidence of association with EC (OR = 0.92; P = 0.03). Overall, however, there was no good evidence that the set of CRC polymorphisms was associated with EC risk, and neither of two previously-reported EC polymorphisms was associated with CRC risk. A combined analysis revealed one genome-wide significant polymorphism, rs3184504, on chromosome 12q24 (OR = 1.10, P = 7.23 × 10(-9)) with shared effects on CRC and EC risk. This polymorphism, a missense variant in the gene SH2B3, is also associated with haematological and autoimmune disorders, suggesting that it influences cancer risk through the immune response. Another polymorphism, rs12970291 near gene TSHZ1, was associated with both CRC and EC (OR = 1.26, P = 4.82 × 10(-8)), with the alleles showing opposite effects on the risks of the two cancers.

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyPolymorphism, GeneticAdaptor Proteins, Signal TransducingAllelesColorectal NeoplasmsEndometrial NeoplasmsFemaleHomeodomain ProteinsHumansIntracellular Signaling Peptides and ProteinsMaleNeoplasm ProteinsProteinsRepressor ProteinsAdaptor Proteins, Signal TransducingHomeodomain ProteinsIntracellular Signaling Peptides and ProteinsNeoplasm ProteinsProteinsRepressor ProteinsSH2B3 protein, humanTSHZ1 protein, human

Identifiers

PMID26621817
PMCPMC4664893
OpenAlexW2189635544

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