Evidence map›Paper›PMID 26621715›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2015

Augmenting NMDA receptor signaling boosts experience-dependent neuroplasticity in the adult human brain.

Jennifer K Forsyth, Peter Bachman, Daniel H Mathalon, Brian J Roach, Robert F Asarnow

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

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  8. The NMDA receptor partial agonist d-cycloserine does not enhance motor learning.Journal of psychopharmacology (Oxford, England) · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Jennifer K ForsythDepartment of Psychology, University of California, Los Angeles, CA 90095;
Peter BachmanDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213;
Daniel H MathalonDepartment of Psychiatry, University of California, San Francisco, CA 94143; San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121;
Brian J RoachSan Francisco Veterans Affairs Medical Center, San Francisco, CA 94121;
Robert F AsarnowDepartment of Psychology, University of California, Los Angeles, CA 90095; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095 rasarnow@mednet.ucla.edu.
San Francisco VA Medical Center · USNeurobehavioral Systems · USUniversity of California, Los Angeles · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experience-dependent plasticity is a fundamental property of the brain. It is critical for everyday function, is impaired in a range of neurological and psychiatric disorders, and frequently depends on long-term potentiation (LTP). Preclinical studies suggest that augmenting N-methyl-d-aspartate receptor (NMDAR) signaling may promote experience-dependent plasticity; however, a lack of noninvasive methods has limited our ability to test this idea in humans until recently. We examined the effects of enhancing NMDAR signaling using d-cycloserine (DCS) on a recently developed LTP EEG paradigm that uses high-frequency visual stimulation (HFvS) to induce neural potentiation in visual cortex neurons, as well as on three cognitive tasks: a weather prediction task (WPT), an information integration task (IIT), and a n-back task. The WPT and IIT are learning tasks that require practice with feedback to reach optimal performance. The n-back assesses working memory. Healthy adults were randomized to receive DCS (100 mg; n = 32) or placebo (n = 33); groups were similar in IQ and demographic characteristics. Participants who received DCS showed enhanced potentiation of neural responses following repetitive HFvS, as well as enhanced performance on the WPT and IIT. Groups did not differ on the n-back. Augmenting NMDAR signaling using DCS therefore enhanced activity-dependent plasticity in human adults, as demonstrated by lasting enhancement of neural potentiation following repetitive HFvS and accelerated acquisition of two learning tasks. Results highlight the utility of considering cellular mechanisms underlying distinct cognitive functions when investigating potential cognitive enhancers.

Indexed as

Neuronal PlasticitySignal TransductionAdultBrainCycloserineDemographyEvoked Potentials, VisualFemaleHumansLearningLong-Term PotentiationMalePhotic StimulationPlacebosReceptors, N-Methyl-D-AspartateTask Performance and AnalysisCycloserinePlacebosReceptors, N-Methyl-D-Aspartated-cycloserinelearninglong-term potentiationneuroplasticityNMDA receptor

Identifiers

PMID26621715
PMCPMC4687562
OpenAlexW2184424486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.