ArticleProceedings of the National Academy of Sciences of the United States of America2015
Protein-like proton exchange in a synthetic host cavity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Temporal nanofluid environments induce prebiotic condensation in water.Communications chemistry · 2023Article
- Toward Coordination Cages with Hybrid Chirality: Amino Acid-Induced Chirality on Metal Centers.Inorganic chemistry · 2022Article
- Catalytic Principles from Natural Enzymes and Translational Design Strategies for Synthetic Catalysts.ACS central science · 2021Review
- An isolated water droplet in the aqueous solution of a supramolecular tetrahedral cage.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Interplay of water and a supramolecular capsule for catalysis of reductive elimination reaction from gold.Nature communications · 2020Article
- Excitation Energy Delocalization and Transfer to Guests within MJournal of the American Chemical Society · 2017Article
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Authors and funding
6 authors.
Funding
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Abstract
The mechanism of proton exchange in a metal-ligand enzyme active site mimic (compound 1) is described through amide hydrogen-deuterium exchange kinetics. The type and ratio of cationic guest to host in solution affect the rate of isotope exchange, suggesting that the rate of exchange is driven by a host whose cavity is occupied by water. Rate constants for acid-, base-, and water-mediated proton exchange vary by orders of magnitude depending on the guest, and differ by up to 200 million-fold relative to an alanine polypeptide. These results suggest that the unusual microenvironment of the cavity of 1 can dramatically alter the reactivity of associated water by magnitudes comparable to that of enzymes.
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