Trial reportEuropean journal of nutrition2017
Role of selected amino acids on plasma IGF-I concentration in infants.
Trial report in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01094080 (Formula With Modified Content of Protein and Improved Fatty Acids and Their Impact on Infant Growth and Health), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Formula With Modified Content of Protein and Improved Fatty Acids and Their Impact on Infant Growth and Health
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Branched-chain amino acid supplementation for improving growth and development in term and preterm neonates.The Cochrane database of systematic reviews · 2020Pooled it
- Infant Feeding Choices during the First Post-Natal Months and Anthropometry at Age Seven Years: Follow-Up of a Randomized Clinical Trial.Nutrients · 2022Trial
- Trial
- Associations of protein intake in early childhood with body composition, height, and insulin-like growth factor I in mid-childhood and early adolescence.The American journal of clinical nutrition · 2019Trial
- Association of infant formula composition and anthropometry at 4 years: Follow-up of a randomized controlled trial (BeMIM study).PloS one · 2018Trial
- Plasma amino acids after human milk fortification and associations with growth in preterm infants.Pediatric research · 2026Article
- Plasma Amino Acids as Correlates of Serum Insulin-Like Growth Factor 1, Linear Growth, and Fat-Free Mass: A Cross-Sectional Study among Ugandan Children with Stunting.The Journal of nutrition · 2026Article
- The Impact of Maternal Supplementation of Fish Oil and/or Probiotics During Pregnancy on the Serum Metabolomic Profile From Infancy to Childhood: Secondary Analysis of a Randomized Placebo-Controlled Trial.Current developments in nutrition · 2025Article
- Dietary protein sources in concentrate supplementation influence growth performance by manipulating gut microbiota and serum metabolites in suckling Donkey foals.Animal microbiome · 2025Article
- The effects of formula milk on development, nutrient absorption, and immune characteristics of piglets.BMC genomics · 2025Article
- Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index.Pediatric obesity · 2022Article
- Regulation of GH and GH Signaling by Nutrients.Cells · 2021Review
- Lifetime Impact of Cow's Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration.Biomolecules · 2021Review
- Impact of early rapid weight gain on odds for overweight at one year differs between breastfed and formula-fed infants.Pediatric obesity · 2020Article
- Impact of a high-protein diet during lactation on milk composition and offspring in a pig model.European journal of nutrition · 2019Article
- Early feeding of larger volumes of formula milk is associated with greater body weight or overweight in later infancy.Nutrition journal · 2018Article
- The Dipeptide Pro-Gly Promotes IGF-1 Expression and Secretion in HepG2 and Female Mice via PepT1-JAK2/STAT5 Pathway.Frontiers in endocrinology · 2018Article
- Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation.Clinical and translational allergy · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeInsulin-like growth factor-I (IGF-I) is related to growth and its secretion is modified by protein intake in early infancy. We examined the relationship of dietary protein and circulating amino acids on plasma IGF-I levels and early growth.
methodsHealthy formula-fed infants (n = 213) were randomly assigned to receive either a protein-reduced infant formula with alpha-lactalbumin-enriched whey and free tryptophan and phenylalanine (IF) or an isocaloric standard formula without free amino acids (CF) for the first 120 days of life. A group of breastfed (BF) infants was studied as a non-randomized reference cohort. Biochemical variables were measured shortly after birth (subpopulation) and at an age of 120 days. A path analysis was used to explore the relationship between IGF-I, insulin and amino acids. Results are derived from secondary analyses of a randomized controlled trial.
resultsPlasma concentrations of IGF-I at 120 days were significantly higher in IF than in CF infants [58.5 (15.0) vs. 53.7 (9.95) ng/mL; p = 0.020]. BF infants showed lower IGF-I concentrations of 41.6 (10.7) ng/mL. All amino acids but Thr and Cit had a more marked effect on insulin than on IGF-I level. Considering weight, sex and feeding group, Trp explained an equal percentage of variance of IGF-I and insulin (total R
conclusionHigher IGF-I concentrations and growth velocities in infants receiving protein-reduced IF indicate that the protein concentration of an infant formula alone does not control IGF-I levels and growth. Other components (e.g., selected amino acids) of infant formulae might control directly or indirectly via insulin influence IGF-I.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.