Evidence map›Paper›PMID 26621503›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2016

HDAC9, TWIST1 and FERD3L gene expression in asymptomatic stable and unstable carotid plaques.

Silvia Ferronato, Matteo Gelati, Alberto Scuro, Silvia Olivato, Giovanni Malerba, Maria Grazia Romanelli, Macarena Gomez-Lira, Carlo Setacci

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Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Silvia FerronatoDepartment of Neurological, Biomedical and Movement Sciences, Section of Biology and Genetics, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.
Matteo GelatiDepartment of Neurological, Biomedical and Movement Sciences, Section of Biology and Genetics, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.
Alberto ScuroDepartment of Surgery, University of Verona, Verona, Italy.
Silvia OlivatoDepartment of Neurological, Biomedical and Movement Sciences, Section of Biology and Genetics, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.
Giovanni MalerbaDepartment of Neurological, Biomedical and Movement Sciences, Section of Biology and Genetics, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.
Maria Grazia RomanelliDepartment of Neurological, Biomedical and Movement Sciences, Section of Biology and Genetics, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy. mariagrazia.romanelli@univr.it.
Macarena Gomez-LiraDepartment of Neurological, Biomedical and Movement Sciences, Section of Biology and Genetics, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy.
Carlo SetacciDivision of Vascular Surgery, University of Siena, Siena, Italy.
University of Verona · ITUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesA variant located at the end of HDAC9 gene within clusters of DNAse I sensitivity zones and histone modification hotspots has been associated with large vessel stroke and could be linked to plaque instability. The aim of the study is to define if an altered expression of HDAC9, TWIST1 and FERD3L genes could be involved in plaque vulnerability.

methodsHistological classification and gene expression analysis were performed in 6 stable and 16 unstable plaques obtained from asymptomatic patients undergoing endarterectomy. Gene expression was analysed by real-time PCR. RESULTS AND

conclusionsTWIST1 gene expression resulted higher in stable plaques (P < 0.02). HDAC9 gene expression followed a similar trend (P = 0.11). These results highlighting the significant correlation between TWIST and HDAC9 gene expression suggest that both genes may contribute to plaque stability in a coordinated way.

Indexed as

AgedAged, 80 and overCarotid Artery DiseasesFemaleGene ExpressionHistone DeacetylasesHumansMaleMyogenic Regulatory FactorsNuclear ProteinsPlaque, AtheroscleroticRepressor ProteinsTwist-Related Protein 1FERD3L protein, humanHDAC9 protein, humanHistone DeacetylasesMyogenic Regulatory FactorsNuclear ProteinsRepressor ProteinsTWIST1 protein, humanTwist-Related Protein 1Carotid plaques instabilityHDAC9, TWIST1, FERD3L gene expressionPolymorphism

Identifiers

PMID26621503
OpenAlexW2291191583

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.