Evidence map›Paper›PMID 26621283›Full record

ArticleParasitology research2016

Molecular identification and characterization of prohibitin from Echinococcus granulosus.

Xiuqin Zhong, Xingju Song, Ning Wang, Dandan Hu, Tinayu Liu, Tao Wang, Xiaobin Gu, Weimin Lai, Xuerong Peng, Guangyou Yang

Abstract read
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In one paragraph

Article in Parasitology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xiuqin ZhongDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Huimin Road, 211#, Chengdu, 611130, Sichuan Province, China.
Xingju SongDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Huimin Road, 211#, Chengdu, 611130, Sichuan Province, China.
Ning WangDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Huimin Road, 211#, Chengdu, 611130, Sichuan Province, China.
Dandan HuDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Huimin Road, 211#, Chengdu, 611130, Sichuan Province, China.
Tinayu LiuDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Huimin Road, 211#, Chengdu, 611130, Sichuan Province, China.
Tao WangDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Huimin Road, 211#, Chengdu, 611130, Sichuan Province, China.
Xiaobin GuDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Huimin Road, 211#, Chengdu, 611130, Sichuan Province, China.
Weimin LaiDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Huimin Road, 211#, Chengdu, 611130, Sichuan Province, China.
Xuerong PengDepartment of Chemistry, College of Life and Basic Science, Sichuan Agricultural University, Ya'an, China.
Guangyou YangDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Huimin Road, 211#, Chengdu, 611130, Sichuan Province, China. guangyou1963@aliyun.com.
Sichuan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prohibitin (PHB) is a widely distributed protein that functions as a molecular chaperone, is involved in the regulation of cell cycle, and maintains mitochondrial structure and functions of the anti-apoptosis, senescence, and proliferation. The aim of this study was to characterize PHB in Echinococcus granulosus (EgPHB), a harmful cestode parasite of humans, many livestock species, and wild animals. We found that EgPHB is a conserved SPFH (stomatin, prohibitin, flotillin, and HflK/C) domain-containing protein, consisting of 289 amino acids, which shares 42.66-99.31% identity with PHBs from other parasites and mammals. EgPHB was located mainly in the tegument issue of protoscoleces, in the inner body of adult worms, and was expressed widely in the germinal layer. This is the first report on prohibitin from E. granulosus, and EgPHB is considered to be a valuable protein to study more in the future.

Indexed as

Amino Acid SequenceAnimalsBase SequenceEchinococcosisEchinococcus granulosusHelminth ProteinsHumansMaleMolecular Sequence DataPhylogenyProhibitinsProtein DomainsRabbitsRepressor ProteinsSequence AlignmentSequence Analysis, DNAHelminth ProteinsPHB protein, humanProhibitinsRepressor ProteinsEchinococcus granulosusImmunohistochemical localizationProhibitinWestern blotting

Identifiers

PMID26621283
OpenAlexW2182796671

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.