ArticleScientific reports2015
Adaptation to sustained nitrogen starvation by Escherichia coli requires the eukaryote-like serine/threonine kinase YeaG.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Global proteolysis during starvation governs proteome remodeling and a survival-regrowth trade-off in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Maltose aids in the growth ofFEMS microbes · 2026Article
- Global Hfq-mediated RNA interactome of nitrogen starved Escherichia coli uncovers a conserved post-transcriptional regulatory axis required for optimal growth recovery.Nucleic acids research · 2024Article
- Single-cell analysis reveals that cryptic prophage protease LfgB protectsMicrobiology spectrum · 2024Article
- Zinc effects on bacteria: insights frommSystems · 2023Article
- Serving Two Masters: Effect ofAntibiotics (Basel, Switzerland) · 2023Article
- Identification of serine/threonine kinases that regulate metabolism and sporulation in Clostridium beijerinckii.Applied microbiology and biotechnology · 2022Article
- A 3' UTR-derived small RNA connecting nitrogen and carbon metabolism in enteric bacteria.Nucleic acids research · 2022Article
- Integrative Physiological and Transcriptome Analysis Reveals the Mechanism for the Repair of Sub-Lethally InjuredFoods (Basel, Switzerland) · 2022Article
- The role of K63-linked polyubiquitin in several types of autophagy.Biologia futura · 2022Review
- RNA-Seq Provides New Insights into the Gene Expression Changes inMicroorganisms · 2021Article
- Transcriptional profiling of the stringent response mutant strain E. coli SR reveals enhanced robustness to large-scale conditions.Microbial biotechnology · 2021Article
- Phosphoproteome Study ofFrontiers in microbiology · 2021Article
- Escherichia coli YegI is a novel Ser/Thr kinase lacking conserved motifs that localizes to the inner membrane.FEBS letters · 2020Article
- The RNA-binding protein Hfq assembles into foci-like structures in nitrogen starvedThe Journal of biological chemistry · 2020Article
- The Adaptive Response to Long-Term Nitrogen Starvation inJournal of bacteriology · 2020Article
- Wide lag time distributions break a trade-off between reproduction and survival in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A Primary Physiological Role of Toxin/Antitoxin Systems Is Phage Inhibition.Frontiers in microbiology · 2020Review
- The expanded specificity and physiological role of a widespread N-degron recognin.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Nitrogen Starvation Induces Persister Cell Formation in Escherichia coli.Journal of bacteriology · 2019Article
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8 authors.
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Abstract
The Escherichia coli eukaryote-like serine/threonine kinase, encoded by yeaG, is expressed in response to diverse stresses, including nitrogen (N) starvation. A role for yeaG in bacterial stress response is unknown. Here we reveal for the first time that wild-type E. coli displays metabolic heterogeneity following sustained periods of N starvation, with the metabolically active population displaying compromised viability. In contrast, such heterogeneity in metabolic activity is not observed in an E. coli ∆yeaG mutant, which continues to exist as a single and metabolically active population and thus displays an overall compromised ability to survive sustained periods of N starvation. The mechanism by which yeaG acts, involves the transcriptional repression of two toxin/antitoxin modules, mqsR/mqsA and dinJ/yafQ. This, consequently, has a positive effect on the expression of rpoS, the master regulator of the general bacterial stress response. Overall, results indicate that yeaG is required to fully execute the rpoS-dependent gene expression program to allow E. coli to adapt to sustained N starvation and unravels a novel facet to the regulatory basis that underpins adaptive response to N stress.
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