ArticleScientific reports2015
Comparative proteomic analysis of compartmentalised Ras signalling.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass.The Biochemical journal · 2026Review
- Golgi Drivers of Cancer.Sub-cellular biochemistry · 2026Review
- ERAS Is Constitutively Expressed in the Tissues of Adult Horses and May Be a Key Player in Basal Autophagy.Frontiers in veterinary science · 2022Article
- The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.Molecular cell · 2019Article
- A model for RAS mutation patterns in cancers: finding the sweet spot.Nature reviews. Cancer · 2018Review
- KRAS mutant allele-specific expression knockdown in pancreatic cancer model with systemically delivered bi-shRNA KRAS lipoplex.PloS one · 2018Article
- A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.Cell reports · 2017Article
- Detection of COPB2 as a KRAS synthetic lethal partner through integration of functional genomics screens.Oncotarget · 2017Article
- Emerging themes of regulation at the Golgi.Current opinion in cell biology · 2017Review
- The Prognostic Value of HRAS mRNA Expression in Cutaneous Melanoma.BioMed research international · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Ras proteins are membrane bound signalling hubs that operate from both the cell surface and endomembrane compartments. However, the extent to which intracellular pools of Ras can contribute to cell signalling is debated. To address this, we have performed a global screen of compartmentalised Ras signalling. We find that whilst ER/Golgi- and endosomal-Ras only generate weak outputs, Ras localised to the mitochondria or Golgi significantly and distinctly influence both the abundance and phosphorylation of a wide range of proteins analysed. Our data reveal that ~80% of phosphosites exhibiting large (≥1.5-fold) changes compared to control can be modulated by organellar Ras signalling. The majority of compartmentalised Ras-specific responses are predicted to influence gene expression, RNA splicing and cell proliferation. Our analysis reinforces the concept that compartmentalisation influences Ras signalling and provides detailed insight into the widespread modulation of responses downstream of endomembranous Ras signalling.
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Registered trials
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