ArticlePlant physiology2016
A Tandem Array of ent-Kaurene Synthases in Maize with Roles in Gibberellin and More Specialized Metabolism.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57 citing papers in PubMed, 93 citations in OpenAlex.
- ZmWRKY29 Transcriptionally Represses ZmRBOHC to Attenuate ROS Production and Facilitates Gibberella Stalk Rot Susceptibility in Maize.Plant biotechnology journal · 2026Article
- Identification of Potential Candidate Dwarf Genes in Maize by BSA-Seq and Transcriptomic Analyses.Plants (Basel, Switzerland) · 2026Article
- Identification and Analysis of the Terpene Synthases (TPS) Gene Family in Camellia Based on Pan-Genome.Genes · 2026Article
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- Multiomics analysis of gibberellin involved in far-red light-regulated internode elongation in cucumber seedlings.Plant cell reports · 2025Article
- Genomic analysis of terpene synthase family and characterization of ent-kaurene synthase in Chenopodium quinoa.Molecular genetics and genomics : MGG · 2025Article
- Gibberellins: extending the Green Revolution.Journal of experimental botany · 2025Review
- Integrative multi-transcriptomic analysis uncovers core genes and potential defense mechanisms in rice-Magnoporthe oryzae interaction.Plant cell reports · 2025Article
- A genome-wide association study prioritizes VRN1-2 as a candidate gene associated with plant height in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Epibrassinolide RegulatesBiomolecules · 2025Article
- A maize semi-dwarf mutant reveals a GRAS transcription factor involved in brassinosteroid signaling.Plant physiology · 2024Article
- Genome-Wide Identification and Expression Analysis ofInternational journal of molecular sciences · 2024Article
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- A mutation in the brassinosteroid biosynthesis geneHorticulture research · 2024Article
- A dual-subcellular localized β-glucosidase confers pathogen and insect resistance without a yield penalty in maize.Plant biotechnology journal · 2024Article
- The terpene synthase gene family in maize - a clarification of existing community nomenclature.BMC genomics · 2023Article
- ZmEREB92 plays a negative role in seed germination by regulating ethylene signaling and starch mobilization in maize.PLoS genetics · 2023Article
- UV-B irradiation-activated E3 ligase GmILPA1 modulates gibberellin catabolism to increase plant height in soybean.Nature communications · 2023Article
- A gibberellin-deficient maize mutant exhibits altered plant height, stem strength and drought tolerance.Plant cell reports · 2023Article
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8 authors at 3 institutions in 3 countries.
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Abstract
While most commonly associated with its role in gibberellin phytohormone biosynthesis, ent-kaurene also serves as an intermediate in more specialized diterpenoid metabolism, as exemplified by the more than 800 known derived natural products. Among these are the maize kauralexins. However, no ent-kaurene synthases (KSs) have been identified from maize. The maize gibberellin-deficient dwarf-5 (d5) mutant has been associated with a loss of KS activity. The relevant genetic lesion has been previously mapped, and was found here to correlate with the location of the KS-like gene ZmKSL3. Intriguingly, this forms part of a tandem array with two other terpene synthases (TPSs). Although one of these, ZmTPS1, has been previously reported to encode a sesquiterpene synthase, and both ZmTPS1 and that encoded by the third gene, ZmKSL5, have lost the N-terminal γ-domain prototypically associated with KS(L)s, all three genes fall within the KS(L) or TPS-e subfamily. Here it is reported that all three genes encode enzymes that are targeted to the plastid in planta, where diterpenoid biosynthesis is initiated, and which all readily catalyze the production of ent-kaurene. Consistent with the closer phylogenetic relationship of ZmKSL3 with previously identified KSs from cereals, only transcription of this gene is affected in d5 plants. On the other hand, the expression of all three of these genes is inducible, suggesting a role in more specialized metabolism, such as that of the kauralexins. Thus, these results clarify not only gibberellin phytohormone, but also diterpenoid phytoalexin biosynthesis in this important cereal crop plant.
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