ArticleGenetics, selection, evolution : GSE2015
A simple strategy for managing many recessive disorders in a dairy cattle breeding program.
Article in Genetics, selection, evolution : GSE, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 96 citations in OpenAlex.
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- Identification of candidate lethal haplotypes and genomic association with post-natal mortality and reproductive traits in Nellore cattle.Scientific reports · 2023Article
- Performance of Swedish Warmblood fragile foal syndrome carriers and breeding prospects.Genetics, selection, evolution : GSE · 2022Article
- Pre-selection against a lethal recessive allele in breeding schemes with optimum-contribution selection or truncation selection.Genetics, selection, evolution : GSE · 2021Article
- Prevalence of nine genetic defects in Chinese Holstein cattle.Veterinary medicine and science · 2021Article
- Identification of unique ROH regions with unfavorable effects on production and fertility traits in Canadian Holsteins.Genetics, selection, evolution : GSE · 2021Article
- A variance component estimation approach to infer associations between Mendelian polledness and quantitative production and female fertility traits in German Simmental cattle.Genetics, selection, evolution : GSE · 2021Article
- Characterization of a haplotype-reference panel for genotyping by low-pass sequencing in Swiss Large White pigs.BMC genomics · 2021Article
- Infertility due to defective sperm flagella caused by an intronic deletion in DNAH17 that perturbs splicing.Genetics · 2021Article
- Comparison of Gene Editing Versus Conventional Breeding to Introgress theFrontiers in genetics · 2021Article
- Unintended consequences of selection for increased production on the health and welfare of livestock.Archives animal breeding · 2021Review
- KDM2B-associated paunch calf syndrome in Marchigiana cattle.Journal of veterinary internal medicine · 2020Article
- Assessing genomic diversity and signatures of selection in Original Braunvieh cattle using whole-genome sequencing data.BMC genomics · 2020Article
- The importance of controlled mating in honeybee breeding.Genetics, selection, evolution : GSE · 2019Article
- Management of lethal recessive alleles in beef cattle through the use of mate selection software.Genetics, selection, evolution : GSE · 2019Article
- Removal of alleles by genome editing (RAGE) against deleterious load.Genetics, selection, evolution : GSE · 2019Article
- A splice donor variant in CCDC189 is associated with asthenospermia in Nordic Red dairy cattle.BMC genomics · 2019Article
- Simulation of introgression of theTranslational animal science · 2018Article
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh-density single nucleotide polymorphism genotypes have recently been used to identify a number of novel recessive mutations that adversely affect fertility in dairy cattle, as well as to track other conditions such as red coat color and polled. Most current methods for mate allocation fail to consider this information, and it will become increasingly difficult to manage matings as the number of recessive mutations to be accounted for increases.
methodsA modified version of a mating strategy that constrains inbreeding based on genomics (the Pryce method) was developed that also accounts for the economic effects of Mendelian disorders on overall economic merit (modified Pryce method) and compared with random mating, truncation selection, and the Pryce scheme. Several scenarios were considered, including scenarios with six hypothetical recessive alleles and 12 recessive alleles that are currently segregating in the US Holstein population.
resultsThe Pryce method and the modified Pryce method showed similar ability to reduce frequencies of recessive alleles, particularly for loci with frequencies greater than 0.30. The modified Pryce method outperformed the Pryce method for low-frequency alleles with small economic value. Cumulative genetic gain for the selection objective was slightly greater when using the Pryce method, but rates of inbreeding were similar across methods.
conclusionsThe proposed method reduces allele frequencies faster than other methods, and also can be used to maintain or increase the frequency of desirable recessives. It can be easily implemented in software for mate allocation, and the code used in this study is freely available as a reference implementation.
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