ArticleNature communications2015
The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- Distinct neural circuits processing pleasant and unpleasant sounds: an fMRI-based approach.BMC neuroscience · 2025Article
- Polyunsaturated fatty-acids diet increases fear discrimination in rats and IGF-2 receptors signaling in the auditory cortex.Scientific reports · 2025Article
- Context flexibly modulates cue representations in visual cortex.Nature communications · 2025Article
- Local inhibitory circuits mediate cortical reactivations and memory consolidation.Science advances · 2025Article
- Gastrin-releasing peptide is essential for generalization of auditory conditioned fear under stress.Molecular brain · 2025Article
- Multisensory integration of social signals by a pathway from the basal amygdala to the auditory cortex in maternal mice.Current biology : CB · 2025Article
- Overgeneralization of autonomic defensive reactions in obesity.Scientific reports · 2024Article
- Article
- Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity.Cell reports · 2024Article
- Targeting Histamine and Histamine Receptors for Memory Regulation: An Emotional Perspective.Current neuropharmacology · 2024Review
- Stabilizing Immature Dendritic Spines in the Auditory Cortex: A Key Mechanism for mTORC1-Mediated Enhancement of Long-Term Fear Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Organization of orbitofrontal-auditory pathways in the Mongolian gerbil.The Journal of comparative neurology · 2023Article
- Prior fear learning enables the rapid assimilation of new fear memories directly into cortical networks.PLoS biology · 2022Article
- Pattern differentiation and tuning shift in human sensory cortex underlie long-term threat memory.Current biology : CB · 2022Article
- Dissociated Role of Thalamic and Cortical Input to the Lateral Amygdala for Consolidation of Long-Term Fear Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Human Sensory Cortex Contributes to the Long-Term Storage of Aversive Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- State Transitions During Discrimination Learning in the Gerbil Auditory Cortex Analyzed by Network Causality Metrics.Frontiers in systems neuroscience · 2021Article
- A critical role of hippocampus for formation of remote cued fear memory.Molecular brain · 2020Article
- Cortical reactivations of recent sensory experiences predict bidirectional network changes during learning.Nature neuroscience · 2020Article
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Authors and funding
7 authors.
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Abstract
The sensory cortex participates in emotional memory but its role is poorly understood. Here we show that inactivation of the higher order auditory cortex Te2 in rats during early memory consolidation impairs remote first- and second-order fear memories but not the association between two neutral cues. Furthermore, Te2 inactivation prevents changes in the valence of such information. Following the presentation of two auditory cues previously paired with either pleasant or painful stimuli, a large percentage of cells responds to both experiences but also a small fraction of neurons responds exclusively to one of them. The latter type of neurons signals the valence rather than the salience or the motor responses associated with the stimuli, and reflects selective associative processes. Pharmacogenetic silencing of memory-activated neurons causes amnesia. Thus, Te2 represents a crucial node for the assignment of the affective value to sensory stimuli and for the storage of such information.
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