ArticleGenome biology2015
Glucocorticoid receptor and nuclear factor kappa-b affect three-dimensional chromatin organization.
Article in Genome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- Coordinated Temporal Dynamics of Glucocorticoid Receptor Binding and Chromatin Landscape Drive Transcriptional Regulation.bioRxiv : the preprint server for biology · 2026Article
- Prolonged fasting and glucocorticoid exposure drive dynamic DNA methylation in northern elephant seals.The Journal of experimental biology · 2025Article
- Impact of glucocorticoid receptor polymorphism rs6198 on sepsis survival in a prospective multicenter cohort.Scientific reports · 2025Article
- Article
- Long-range gene regulation in hormone-dependent cancer.Nature reviews. Cancer · 2023Review
- Exploring the impact of dexamethasone on gene regulation in myeloma cells.Life science alliance · 2023Article
- Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation.Developmental cell · 2023Article
- An Expanded Interplay Network between NF-κB p65 (RelA) and E2F1 Transcription Factors: Roles in Physiology and Pathology.Cancers · 2022Article
- Article
- Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation.Cell reports · 2021Article
- Role of Non-Coding Regulatory Elements in the Control of GR-Dependent Gene Expression.International journal of molecular sciences · 2021Article
- Review
- Obesity and endocrine-disrupting chemicals.Endocrine connections · 2021Review
- Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers.Cell reports · 2020Article
- Environmental Obesogens and Their Impact on Susceptibility to Obesity: New Mechanisms and Chemicals.Endocrinology · 2020Review
- Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migration.Disease models & mechanisms · 2019Article
- Extensive epigenomic integration of the glucocorticoid response in primary human monocytes and in vitro derived macrophages.Scientific reports · 2019Article
- Hormone-control regions mediate steroid receptor-dependent genome organization.Genome research · 2019Article
- Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding.Genome research · 2018Article
- Clock-dependent chromatin topology modulates circadian transcription and behavior.Genes & development · 2018Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe impact of signal-dependent transcription factors, such as glucocorticoid receptor and nuclear factor kappa-b, on the three-dimensional organization of chromatin remains a topic of discussion. The possible scenarios range from remodeling of higher order chromatin architecture by activated transcription factors to recruitment of activated transcription factors to pre-established long-range interactions.
resultsUsing circular chromosome conformation capture coupled with next generation sequencing and high-resolution chromatin interaction analysis by paired-end tag sequencing of P300, we observed agonist-induced changes in long-range chromatin interactions, and uncovered interconnected enhancer-enhancer hubs spanning up to one megabase. The vast majority of activated glucocorticoid receptor and nuclear factor kappa-b appeared to join pre-existing P300 enhancer hubs without affecting the chromatin conformation. In contrast, binding of the activated transcription factors to loci with their consensus response elements led to the increased formation of an active epigenetic state of enhancers and a significant increase in long-range interactions within pre-existing enhancer networks. De novo enhancers or ligand-responsive enhancer hubs preferentially interacted with ligand-induced genes.
conclusionsWe demonstrate that, at a subset of genomic loci, ligand-mediated induction leads to active enhancer formation and an increase in long-range interactions, facilitating efficient regulation of target genes. Therefore, our data suggest an active role of signal-dependent transcription factors in chromatin and long-range interaction remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.