SynthesisClinical drug investigation2016
The Impact of Endocrine Therapy on Cognitive Functions of Breast Cancer Patients: A Systematic Review.
Synthesis in Clinical drug investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cognitive impairment following breast cancer treatments: an umbrella review.The oncologist · 2024Pooled it
- Prevalence of cognitive impairment and change in patients with breast cancer: A systematic review of longitudinal studies.Psycho-oncology · 2021Pooled it
- Training Cognitive Functions Using Mobile Apps in Breast Cancer Patients: Systematic Review.JMIR mHealth and uHealth · 2019Pooled it
- Role of individualized intervention(s) on quality of life and adherence to adjuvant endocrine therapy in premenopausal women with early-stage breast cancer: MyCHOICE study.Breast cancer research and treatment · 2026Trial
- Selective oestrogen receptor modulators and Alzheimer´s disease: a real-world pharmacovigilance study.European journal of clinical pharmacology · 2026Article
- Review
- Insights Into the Patient Experience of Hormone Therapy for Early Breast Cancer Treatment Using Patient Forum Discussions and Natural Language Processing.JCO clinical cancer informatics · 2024Article
- Design and methods of the mobile assessment of cognition, environment, and sleep (MACES) feasibility study in newly diagnosed breast cancer patients.Scientific reports · 2024Article
- Article
- [Impact of physical activity before, during, and after chemotherapy on cognitive functions in patients with breast cancer: results of a prospective US study].Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022Article
- Perspectives and limits of cancer treatment in an oldest old population.Aging clinical and experimental research · 2021Article
- Effect of chronic intracerebroventricular administration of an aromatase inhibitor on the expression of socio-sexual behaviors in male Japanese quail.Behavioural brain research · 2021Article
- Neuropsychiatric effects of tamoxifen: Challenges and opportunities.Frontiers in neuroendocrinology · 2020Review
- Type of cancer treatment and cognitive symptoms in working cancer survivors: an 18-month follow-up study.Journal of cancer survivorship : research and practice · 2020Article
- Neuroimmunology of the female brain across the lifespan: Plasticity to psychopathology.Brain, behavior, and immunity · 2019Review
- The Working Memory and Dorsolateral Prefrontal-Hippocampal Functional Connectivity Changes in Long-Term Survival Breast Cancer Patients Treated with Tamoxifen.The international journal of neuropsychopharmacology · 2017Article
- Cognitive impairment following hormone therapy: current opinion of research in breast and prostate cancer patients.Current opinion in supportive and palliative care · 2017Review
- The relationship of cognitive performance to concurrent symptoms, cancer- and cancer-treatment-related variables in women with early-stage breast cancer: a 2-year longitudinal study.Journal of cancer research and clinical oncology · 2016Article
- Cognitive Functioning and Psychological Well-being in Breast Cancer Patients on Endocrine Therapy.In vivo (Athens, Greece)Article
- Perceived cognitive functioning and its influence on emotional vulnerability in breast cancer.Health psychology openArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveThe purpose of the present review was to study the impact of endocrine therapy (ET) on the cognitive outcomes of breast cancer patients. MATERIALS AND
methodsWe systematically searched the literature using the MEDLINE (1966-2015), Scopus (2004-2015), ClinicalTrials.gov (2008-2015) and Cochrane Central Register (CENTRAL) databases, as well as the references of the electronically retrieved articles.
resultsTwelve studies were included in the present systematic review, which assessed the cognitive function of 2756 patients. Among these patients, 2381 received ET, whereas the remaining 375 served as controls (placebo or no therapy). The majority of patients were postmenopausal, and the minimum follow-up period was 3 months and the maximum 2 years. Treatment with ET seems to be accompanied by altered cognitive abilities, including verbal memory, verbal fluency, motor speed, attention and working memory. Tamoxifen seems to be related to decreased cognitive performances compared with treatment with an aromatase inhibitor.
conclusionsET among breast cancer patients seems to negatively alter the cognitive outcomes of breast cancer patients. However, the methodological heterogeneity of the included studies, as well as the relatively small follow-up period, render imperative the conduct of further studies in the field.
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Registered trials
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