ArticleScientific reports2015
Lactic acid is a sperm motility inactivation factor in the sperm storage tubules.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 75 citations in OpenAlex.
- Alterations in the protein lactylation landscape of sperm from patients with varicocele-associated asthenozoospermia.Frontiers in endocrinology · 2026Article
- Proteome Analysis of Spermathecal Fluid and Seminal Plasma Reveals the Mechanism of Sperm Storage inAnimals : an open access journal from MDPI · 2025Article
- Relative testis size is associated with vagina length but not sperm storage traits in Galliformes.Evolution letters · 2025Article
- Unique Physiological Mechanisms of Sperm Storage and Prolonged Sperm Survival in Hen Oviducts: A Review.The journal of poultry science · 2025Review
- Revisiting the Injury Mechanism of Goat Sperm Caused by the Cryopreservation Process from a Perspective of Sperm Metabolite Profiles.International journal of molecular sciences · 2024Article
- The surprising complexity and diversity of sperm storage structures across Galliformes.Ecology and evolution · 2024Article
- Arresting calcium-regulated sperm metabolic dynamics enables prolonged fertility in poultry liquid semen storage.Scientific reports · 2023Article
- Article
- Transcriptome identification of genes associated with uterus-vagina junction epithelial folds formation in chicken hens.Poultry science · 2023Article
- A novel protein encoded by circRsrc1 regulates mitochondrial ribosome assembly and translation during spermatogenesis.BMC biology · 2023Article
- Near-anoxia induces immobilization and sustains viability of sperm stored in ant queens.Scientific reports · 2023Article
- Supplementation of Schisandrin B in Semen Extender Improves Quality and Oxidation Resistance of Boar Spermatozoa Stored at 4 °C.Animals : an open access journal from MDPI · 2023Article
- New insights into sperm rheotaxis, agglutination and bundle formation in Sharkasi chickens based on an in vitro study.Scientific reports · 2022Article
- Effect of vitamin E supplementation on chicken sperm quality: A meta-analysis.Veterinary world · 2022Article
- Sperm Motility Regulation in Male and Female Bird Genital Tracts.The journal of poultry science · 2022Article
- Physiological factors influencing female fertility in birds.Royal Society open science · 2021Review
- A 150 kDa Protein Derived from Bull Seminal Plasma Extended the Survival Time of Kacang Goat Sperm Stored at 5°C.Veterinary medicine international · 2021Article
- Transcriptome analysis and identification of genes associated with chicken sperm storage duration.Poultry science · 2020Article
- Expression of Transferrin and Albumin in the Sperm-Storage Tubules of Japanese Quail and their Possible Involvement in Long-Term Sperm Storage.The journal of poultry science · 2020Article
- Detrimental effects of excessive fatty acid secretion on female sperm storage in chickens.Journal of animal science and biotechnology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although successful fertilization depends on timely encounters between sperm and egg, the decoupling of mating and fertilization often confers reproductive advantages to internally fertilizing animals. In several vertebrate groups, postcopulatory sperm viability is prolonged by storage in specialized organs within the female reproductive tract. In birds, ejaculated sperm can be stored in a quiescent state within oviductal sperm storage tubules (SSTs), thereby retaining fertilizability for up to 15 weeks at body temperature (41°C); however, the mechanism by which motile sperm become quiescent within SSTs is unknown. Here, we show that low oxygen and high lactic acid concentrations are established in quail SSTs. Flagellar quiescence was induced by lactic acid in the concentration range found in SSTs through flagellar dynein ATPase inactivation following cytoplasmic acidification (<pH 6.0). The long-term preservation of sperm morphology under hypoxic and high temperature conditions indicates that a combination of these factors enables sperm cells to survive during the ovulation cycles. Our findings suggested a novel physiological role for lactic acid in promoting sperm quiescence in SSTs and opened up a new opportunity for technological improvement in prolonging sperm longevity at ambient or body temperature.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.