ArticlePsycho-oncology2016
The association of mood disorders with breast cancer survival: an investigation of linked cancer registration and hospital admission data for South East England.
Article in Psycho-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Manic and hypomanic states in cancer patients: A systematic review.Palliative & supportive care · 2026Pooled it
- Prognostic value of depression and anxiety on breast cancer recurrence and mortality: a systematic review and meta-analysis of 282,203 patients.Molecular psychiatry · 2020Pooled it
- A Longitudinal Correlational Study of Psychological Resilience, Depression Disorder, and Brain Functional-Structural Hybrid Connectome in Breast Cancer.Depression and anxiety · 2024Trial
- Bipolar Disorder Versus Unipolar Depressive Disorder in Female Psycho-Oncology Outpatients With Breast Cancer.Psychiatry investigation · 2026Article
- Impact of Pre-Diagnosed Depressive Symptoms on Treatment Choice, Delay in Initiating Treatment, and Mortality Among Women Aged ≥65 Years with Breast Cancer.International journal of environmental research and public health · 2026Article
- Depression and long-term mortality among 5-year breast cancer survivors in Korea: a retrospective population-based cohort study.Scientific reports · 2026Article
- Depression, anxiety, and stress in breast cancer patients: prevalence, associated risk factors, and clinical correlates.Scientific reports · 2025Article
- Stage at diagnosis and breast cancer-specific mortality in breast cancer patients treated with antidepressants, anxiolytics, and antipsychotics: a population-based cohort study from Northern Ireland.Breast cancer research and treatment · 2025Article
- A mixed methods evaluation of patient perspectives on the implementation of an electronic health record-integrated patient-reported symptom and needs monitoring program in cancer care.Journal of patient-reported outcomes · 2024Article
- A study of a PERMA-based positive psychological intervention programme in subthreshold depressed patients with newly diagnosed breast cancer: formulation and application.Frontiers in psychology · 2024Article
- Influence of depression on breast cancer treatment and survival: A Kentucky population-based study.Cancer · 2023Article
- Article
- Characterization of Depressive Symptoms Trajectories After Breast Cancer Diagnosis in Women in France.JAMA network open · 2022Article
- Prevalence and Psychobiological Correlates of Depression Among Breast Cancer Patients.Indian journal of surgical oncology · 2021Review
- Association between preexisting mental illnesses and mortality among medicaid-insured women diagnosed with breast cancer.Social science & medicine (1982) · 2021Article
- Adverse impact of depression and anxiety on mortality in patients with breast cancer.Translational cancer research · 2020Article
- Why are somatic diseases in bipolar disorder insufficiently treated?International journal of bipolar disorders · 2019Review
- A preventive intervention to modify depression risk targets after breast cancer diagnosis: Design and single-arm pilot study.Psycho-oncology · 2019Article
- Feasibility of Synchronous Online Focus Groups of Rural Breast Cancer Survivors on Web-Based Distress Self-Management.Oncology nursing forum · 2018Article
- Predicting future major depression and persistent depressive symptoms: Development of a prognostic screener and PHQ-4 cutoffs in breast cancer patients.Psycho-oncology · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData linkage studies find that depression before or after a breast cancer diagnosis predicts reduced survival. This study aimed to determine whether depression or bipolar recorded in routine hospital admission data independently predicts survival in English breast cancer patients and whether onset in relation to cancer diagnosis is significant.
methodsData on 77,173 women diagnosed with breast cancer (ICD-10 C50) in South East England, 2000-2009, were included. Of these, 131 women had a diagnosis of bipolar affective disorder (ICD-10 F31) and 955 of depression (either depressive episodes (ICD-10 F32) or depressive disorder (ICD-10 F33)) recorded in Hospital Episode Statistics between 3 years before and a year following cancer diagnosis. Kaplan-Meier plots were used to examine overall survival. Cox regression analyses were carried out overall and separately for mood disorder diagnoses before and after the cancer diagnosis and adjusted for confounding variables.
resultsA record of depression was a predictor of worse overall survival in breast cancer patients (adjusted HR = 1.33, 95% CI: 1.20-1.48, p < 0.001), while the effect of bipolar was not statistically significant (adjusted HR = 1.33, 95% CI: 0.97-1.82, p = 0.079). New recordings of depression and bipolar diagnoses following a cancer diagnosis appeared better predictors of overall survival than a prior history of either.
conclusionsThere is evidence that English breast cancer patients with depression and bipolar recorded in routine hospital data have worse overall survival than those without these mood disorders. Further work exploring the concordance of records within administrative health data with clinical diagnosis and cause-specific death within these patient groups is needed.
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