ArticleMolecular plant pathology2016
A highly conserved metalloprotease effector enhances virulence in the maize anthracnose fungus Colletotrichum graminicola.
Article in Molecular plant pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed, 83 citations in OpenAlex.
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- Establishment of an experimental system to analyse extracellular vesicles during apoplastic fungal pathogenesis.Journal of extracellular biology · 2025Article
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- Template-Based Modelling of the Structure of Fungal Effector Proteins.Molecular biotechnology · 2024Article
- A perspective on varied fungal virulence factors causing infection in host plants.Molecular biology reports · 2024Review
- Svx Peptidases of Phytopathogenic Pectolytic Bacteria: Structural, Catalytic and Phytoimmune Properties.International journal of molecular sciences · 2024Article
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- A secreted protease-like protein in Zymoseptoria tritici is responsible for avirulence on Stb9 resistance gene in wheat.PLoS pathogens · 2023Article
- The Cytosolic Acetoacetyl-CoA Thiolase TaAACT1 Is Required for Defense againstInternational journal of molecular sciences · 2023Article
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- Mycoparasites, Gut Dwellers, and Saprotrophs: Phylogenomic Reconstructions and Comparative Analyses of Kickxellomycotina Fungi.Genome biology and evolution · 2023Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colletotrichum graminicola causes maize anthracnose, an agronomically important disease with a worldwide distribution. We have identified a fungalysin metalloprotease (Cgfl) with a role in virulence. Transcriptional profiling experiments and live cell imaging show that Cgfl is specifically expressed during the biotrophic stage of infection. To determine whether Cgfl has a role in virulence, we obtained null mutants lacking Cgfl and performed pathogenicity and live microscopy assays. The appressorium morphology of the null mutants is normal, but they exhibit delayed development during the infection process on maize leaves and roots, showing that Cgfl has a role in virulence. In vitro chitinase activity assays of leaves infected with wild-type and null mutant strains show that, in the absence of Cgfl, maize leaves exhibit increased chitinase activity. Phylogenetic analyses show that Cgfl is highly conserved in fungi. Similarity searches, phylogenetic analysis and transcriptional profiling show that C. graminicola encodes two LysM domain-containing homologues of Ecp6, suggesting that this fungus employs both Cgfl-mediated and LysM protein-mediated strategies to control chitin signalling.
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