ArticlePloS one2015
Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
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- Effects of SLC45A2 and GPNMB on Melanin Deposition Based on Transcriptome Sequencing in Chicken Feather Follicles.Animals : an open access journal from MDPI · 2023Article
- Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway.Frontiers in pharmacology · 2023Article
- Biology of melanocytes in mammals.Frontiers in cell and developmental biology · 2023Review
- Identification of SNPs inFrontiers in genetics · 2023Article
- In vitro disease modeling of oculocutaneous albinism type 1 and 2 using human induced pluripotent stem cell-derived retinal pigment epithelium.Stem cell reports · 2022Article
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- CRTC3, a sensor and key regulator for melanogenesis, as a tunable therapeutic target for pigmentary disorders.Theranostics · 2021Article
- Melanoblasts Populate the Mouse Choroid Earlier in Development Than Previously Described.Investigative ophthalmology & visual science · 2020Article
- Syntenin regulates melanogenesis via the p38 MAPK pathway.Molecular medicine reports · 2020Article
- Delineating the role of MITF isoforms in pigmentation and tissue homeostasis.Pigment cell & melanoma research · 2020Article
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- A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report.Oncology letters · 2018Article
- PIKfyve regulates melanosome biogenesis.PLoS genetics · 2018Article
- Comparative Transcriptome Analysis of Mink (Neovison vison) Skin Reveals the Key Genes Involved in the Melanogenesis of Black and White Coat Colour.Scientific reports · 2017Article
- Highly Efficient Mouse Genome Editing by CRISPR Ribonucleoprotein Electroporation of Zygotes.The Journal of biological chemistry · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The mechanisms that lead to variation in human skin and hair color are not fully understood. To better understand the molecular control of skin and hair color variation, we modulated the expression of Tyrosinase (Tyr), which controls the rate-limiting step of melanogenesis, by expressing a single-copy, tetracycline-inducible shRNA against Tyr in mice. Moderate depletion of TYR was sufficient to alter the appearance of the mouse coat in black, agouti, and yellow coat color backgrounds, even though TYR depletion did not significantly inhibit accumulation of melanin within the mouse hair. Ultra-structural studies revealed that the reduction of Tyr inhibited the accumulation of terminal melanosomes, and inhibited the expression of genes that regulate melanogenesis. These results indicate that color in skin and hair is determined not only by the total amount of melanin within the hair, but also by the relative accumulation of mature melanosomes.
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Registered trials
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