ArticleArthritis care & research2016
Environmental Risk Factors and Early-Life Exposures in Juvenile Idiopathic Arthritis: A Case-Control Study.
Article in Arthritis care & research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Family-Related Factors in Children and Adolescents With Chronic Pain: A Systematic Review.European journal of pain (London, England) · 2025Pooled it
- Is There a Link between the Molecular Basis of Juvenile Idiopathic Arthritis and Autoimmune Diseases? Systematic Review.International journal of molecular sciences · 2024Pooled it
- Moving from nature to nurture: a systematic review and meta-analysis of environmental factors associated with juvenile idiopathic arthritis.Rheumatology (Oxford, England) · 2022Pooled it
- Article
- The gut-joint axis in juvenile idiopathic arthritis.Arthritis research & therapy · 2026Review
- Association between asthma and juvenile idiopathic arthritis in children in the United States: a propensity score weighted cross-sectional study.Pediatric rheumatology online journal · 2026Article
- In utero and early life exposures to smoking are associated with systemic autoimmune rheumatic diseases.Seminars in arthritis and rheumatism · 2025Observational
- Breastfeeding and Non-Communicable Diseases: A Narrative Review.Nutrients · 2025Review
- Development of a machine learning-based predictive nomogram for screening children with juvenile idiopathic arthritis: a pseudo-longitudinal study of 223,195 children in the United States.Frontiers in public health · 2025Article
- The influence of environmental factors related to Juvenile Dermatomyositis (JDM), its course and refractoriness to treatment.Advances in rheumatology (London, England) · 2024Article
- Infant gut microbiota and environment associate with juvenile idiopathic arthritis many years prior to disease onset, especially in genetically vulnerable children.EBioMedicine · 2023Article
- Genetic Background and Molecular Mechanisms of Juvenile Idiopathic Arthritis.International journal of molecular sciences · 2023Review
- The role of breastfeeding as a protective factor against the development of the immune-mediated diseases: A systematic review.Frontiers in pediatrics · 2023Review
- Human Breast Milk: From Food to Active Immune Response With Disease Protection in Infants and Mothers.Frontiers in immunology · 2022Review
- Long-term breastfeeding influences disease activity in a low-income juvenile idiopathic arthritis cohort.Clinical rheumatology · 2019Article
- Evaluation of disease activity in a low-income juvenile idiopathic arthritis cohort.Rheumatology international · 2019Article
- Review of environmental factors and juvenile idiopathic arthritis.Open access rheumatology : research and reviews · 2019Review
- Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis.Multiple sclerosis and related disorders · 2018Article
- Early feeding and risk of Juvenile idiopathic arthritis: a case control study in a prospective birth cohort.Pediatric rheumatology online journal · 2017Article
- Juvenile idiopathic arthritis in relation to perinatal and maternal characteristics: a case control study.Pediatric rheumatology online journal · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveJuvenile idiopathic arthritis (JIA) is a heterogeneous group of disorders characterized by chronic arthritis in children with unknown etiology. Although research evaluating environmental or early-life exposures in JIA is scarce, there are data to suggest that infections, smoking exposure, and lack of breastfeeding play a role. This case-control study investigated the association of selected environmental and early-life risk factors with the development of JIA.
methodsJIA cases were identified at a major pediatric rheumatology outpatient clinic. Each case was asked to identify up to 3 healthy playmates of similar age and same sex to serve as controls. Parents/caregivers of cases and controls completed a questionnaire on selected environmental and early-life exposures. Conditional logistic regression adjusted for age and socioeconomic status was used to determine the odds ratio (OR) for developing JIA with 95% confidence intervals (95% CIs) for the playmate-matched design.
resultsIncluded in the study were 225 JIA cases and 138 controls. Compared to playmate-matched controls, preterm delivery (OR 1.8 [95% CI 1.2-2.7]) was associated with JIA. There was no association between JIA and household smoking or maternal prenatal smoking, breastfeeding, hospitalization with infection in the first year of life, daycare attendance before 6 years of age, household pets, or residential area prior to the onset of JIA.
conclusionThere was no association between the previously reported risk factors of smoking, early-life infection, or breastfeeding and development of JIA in this study. The association of preterm delivery with JIA needs to be further studied.
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