ArticlePloS one2015
Pathology and Epidemiology of Ceruminous Gland Tumors among Endangered Santa Catalina Island Foxes (Urocyon littoralis catalinae) in the Channel Islands, USA.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Ear Mite Removal in the Santa Catalina Island Fox (Urocyon littoralis catalinae): Controlling Risk Factors for Cancer Development.PloS one · 2015Trial
- When cells rebel: a comparative genomics investigation into marsupial cancer susceptibility.Molecular biology and evolution · 2026Article
- Ceruminous Gland Tumors in Canines and Felines: A Scoping Review.Animals : an open access journal from MDPI · 2025Review
- Insights into the prevalence and diagnosis of feline otoacariasis in Egypt.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- Tumor and Tumor-like Lesions in Red Foxes (Animals : an open access journal from MDPI · 2024Article
- Article
- Sea Turtles in the Cancer Risk Landscape: A Global Meta-Analysis of Fibropapillomatosis Prevalence and Associated Risk Factors.Pathogens (Basel, Switzerland) · 2021Article
- Effect of Geography and Captivity on Scat Bacterial Communities in the Imperiled Channel Island Fox.Frontiers in microbiology · 2021Article
- Clinical, ultrasonographic and histopathological diagnosis of ceruminous gland tumors in cats.Veterinary research forum : an international quarterly journal · 2021Article
- Comparative Oncology: New Insights into an Ancient Disease.iScience · 2020Review
- The ecology and evolution of wildlife cancers: Applications for management and conservation.Evolutionary applications · 2020Article
- Cancer in wildlife: patterns of emergence.Nature reviews. Cancer · 2018Review
- Ceruminous Neoplasms of the Ear.Head and neck pathology · 2018Review
- Genetic diversity, inbreeding and cancer.Proceedings. Biological sciences · 2018Review
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Authors and funding
7 authors at 5 institutions in 1 country.
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Abstract
In this study, we examined the prevalence, pathology, and epidemiology of tumors in free-ranging island foxes occurring on three islands in the California Channel Islands, USA. We found a remarkably high prevalence of ceruminous gland tumors in endangered foxes (Urocyon littoralis catalinae) occurring on Santa Catalina Island (SCA)--48.9% of the dead foxes examined from 2001-2008 had tumors in their ears, and tumors were found in 52.2% of randomly-selected mature (≥ 4 years) foxes captured in 2007-2008, representing one of the highest prevalences of tumors ever documented in a wildlife population. In contrast, no tumors were detected in foxes from San Nicolas Island or San Clemente Island, although ear mites (Otodectes cynotis), a predisposing factor for ceruminous gland tumors in dogs and cats, were highly prevalent on all three islands. On SCA, otitis externa secondary to ear mite infection was highly correlated with ceruminous gland hyperplasia (CGH), and tumors were significantly associated with the severity of CGH, ceruminous gland dysplasia, and age group (older foxes). We propose a conceptual model for the formation of ceruminous gland tumors in foxes on SCA that is based on persistent, ubiquitous infection with ear mites, and an innate, over exuberant inflammatory and hyperplastic response of SCA foxes to these mites. Foxes on SCA are now opportunistically treated with acaricides in an attempt to reduce mite infections and the morbidity and mortality associated with this highly prevalent tumor.
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