Evidence map›Paper›PMID 26618447›Full record

Trial reportMedical principles and practice : international journal of the Kuwait University, Health Science Centre2016

Metformin Decreases Thyroid Volume and Nodule Size in Subjects with Insulin Resistance: A Preliminary Study.

Cuneyd Anil, Altug Kut, Berna Atesagaoglu, Asli Nar, Neslihan Bascil Tutuncu, Alptekin Gursoy

Open access · diamondAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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  12. Thyroid Dysfunction and Type 2 Diabetes Mellitus: Screening Strategies and Implications for Management.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cuneyd AnilDepartment of Endocrinology and Metabolism, Baskent University Faculty of Medicine, Ankara, Turkey.
Altug Kut
Berna Atesagaoglu
Asli Nar
Neslihan Bascil Tutuncu
Alptekin Gursoy
Başkent University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to investigate the effects of metformin on thyroid volume and nodule size. SUBJECTS AND

methodsProspective data were gathered on 100 newly diagnosed subjects with insulin resistance (68 female, 32 male) between August 2008 and May 2010. Each subject followed a standard diet and exercise program, and received 1,700 mg/day of metformin therapy for 6 months. The height, weight, waist circumference (WC) and thyroid hormone levels of each subject were measured. Additionally, the dimensions of the thyroid lobes and maximum diameter of each thyroid nodule were determined by ultrasonography. BMI and thyroid volumes were also calculated. Insulin resistance was estimated by homeostasis model assessment. All these parameters were measured at the beginning and at the end of the treatment period.

resultsBMI and WC decreased significantly after metformin therapy (34.5 ± 5.1 vs. 32.7 ± 4.8, p < 0.0001, and 106.3 ± 11.8 vs. 101.8 ± 19.0 cm, p = 0.008, respectively). Insulin resistance also decreased after metformin therapy (4.5 ± 1.9 vs. 2.9 ± 1.7, p < 0.0001). The mean thyroid volume (22.5 ± 11.2 vs. 20.3 ± 10.4 ml, p < 0.0001) and mean thyroid nodule size (12.9 ± 7.6 vs. 11.7 ± 7.2 mm, p < 0.0001) also decreased after treatment.

conclusionIn subjects with insulin resistance, metformin therapy significantly decreased thyroid volume and nodule size.

Indexed as

Insulin ResistanceAdultAgedBody Mass IndexBody Weights and MeasuresDietExerciseHumansHypoglycemic AgentsMaleMetforminMiddle AgedProspective StudiesThyroid GlandThyroid HormonesThyroid NoduleHypoglycemic AgentsMetforminThyroid Hormones

Identifiers

PMID26618447
PMCPMC5588367
OpenAlexW2193486153

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.