ArticleJournal of pathogens2015
Prevalence of Plasmid-Mediated Quinolone Resistance Genes among Extended-Spectrum β -Lactamase-Producing Klebsiella pneumoniae Human Isolates in Iran.
Article in Journal of pathogens, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Distribution and molecular characterization of integron classes fromMicrobiology spectrum · 2025Article
- Prevalence of plasmid-mediated quinolone resistance genes in extended-spectrum beta-lactamase producingHeliyon · 2024Article
- Molecular characterization of superbugsHeliyon · 2024Article
- Investigation of gyrA and parC mutations and the prevalence of plasmid-mediated quinolone resistance genes in Klebsiella pneumoniae clinical isolates.BMC microbiology · 2024Article
- Antibiotic resistance patterns, characteristics of virulence and resistance genes and genotypic analysis ofVeterinary research forum : an international quarterly journal · 2024Article
- Antibiotic Resistance in Non-TyphoidalPathogens (Basel, Switzerland) · 2022Article
- Biofilm Formation and Associated Gene Expression in Multidrug-Resistant Klebsiella pneumoniae Isolated from Clinical Specimens.Current microbiology · 2022Article
- Study on antibiotic resistance and phylogenetic comparison of avian-pathogenicVeterinary research forum : an international quarterly journal · 2022Article
- Frequency ofReports of biochemistry & molecular biology · 2021Article
- Detection of gyrA and parC Mutations and Prevalence of Plasmid-Mediated Quinolone Resistance Genes inInfection and drug resistance · 2021Article
- Plasmid-Mediated Mechanism of Quinolone Resistance onArchives of Razi Institute · 2021Article
- Carriage of ESBL-producing Gram-negative bacteria by flies captured in a hospital and its suburban surroundings in Ethiopia.Antimicrobial resistance and infection control · 2020Article
- Fluoroquinolone Resistance in Clinical Isolates ofJournal of laboratory physicians · 2020Article
- The prevalence of plasmid-mediated quinolone resistance and ESBL-production inInfection and drug resistance · 2018Article
- Molecular Identification of Aminoglycoside-Modifying Enzymes and Plasmid-Mediated Quinolone Resistance Genes amongInternational journal of microbiology · 2017Article
- EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCING GRAM NEGATIVE BACTERIA IN IRAN: A REVIEW.African journal of infectious diseases · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to determine the prevalence and molecular characterization of plasmid-mediated quinolone resistance (PMQR) genes (qnrA, qnrB, qnrS, aac(6')-Ib-cr, and qepA) among ESBL-producing Klebsiella pneumoniae isolates in Kashan, Iran. A total of 185 K. pneumoniae isolates were tested for quinolone resistance and ESBL-producing using the disk diffusion method and double disk synergy (DDST) confirmatory test. ESBL-producing strains were further evaluated for the bla CTX-M genes. The PCR method was used to show presence of plasmid-mediated quinolone resistance genes and the purified PCR products were sequenced. Eighty-seven ESBL-producing strains were identified by DDST confirmatory test and majority (70, 80.5%) of which carried bla CTX-M genes including CTX-M-1 (60%), CTX-M-2 (42.9%), and CTX-M-9 (34.3%). Seventy-seven ESBL-producing K. pneumoniae isolates harbored PMQR genes, which mostly consisted of aac(6')-Ib-cr (70.1%) and qnrB (46.0%), followed by qnrS (5.7%). Among the 77 PMQR-positive isolates, 27 (35.1%) and 1 (1.3%) carried 2 and 3 different PMQR genes, respectively. However, qnrA and qepA were not found in any isolate. Our results highlight high ESBL occurrence with CTX-M type and high frequency of plasmid-mediated quinolone resistance genes among ESBL-producing K. pneumoniae isolates in Kashan.
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