Evidence map›Paper›PMID 26617989›Full record

ArticleCell discovery

Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules.

Nathan D Camp, Kyung-Soon Lee, Jennifer L Wacker-Mhyre, Timothy S Kountz, Ji-Min Park, Dorathy-Ann Harris, Marianne Estrada, Aaron Stewart, Alejandro Wolf-Yadlin, Chris Hague

Open access · goldAbstract read
In one paragraph

Article in Cell discovery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. N-glycosylation of αScientific reports · 2020
    Article
  6. Article
  7. Review
  8. Label-Free Dynamic Mass Redistribution Reveals Low-Density, ProsurvivalThe Journal of pharmacology and experimental therapeutics · 2017
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nathan D CampDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Kyung-Soon LeeDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA.
Jennifer L Wacker-MhyreDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA.
Timothy S KountzDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA.
Ji-Min ParkDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA.
Dorathy-Ann HarrisDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA.
Marianne EstradaDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA.
Aaron StewartDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA.
Alejandro Wolf-YadlinDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Chris HagueDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA.
University of Washington · US

Funding

INTERDISCIPLINARY TRAINING IN GENOMIC SCIENCEST32HG000035 · NHGRI · UNIVERSITY OF WASHINGTON · PI Bruce Colston Trapnell · 1995 to 2026
$24.2M
The a-catulin/dystrophin-associated protein complex regulates GPCR function.R01GM100893 · NIGMS · UNIVERSITY OF WASHINGTON · PI HAGUE, CHRIS S · 2012 to 2020
$2.9M
NHGRI NIH HHS T32 HG000035NIGMS NIH HHS R01 GM100893
6 · The paper itself

Abstract

Recent advances in proteomic technology reveal G-protein-coupled receptors (GPCRs) are organized as large, macromolecular protein complexes in cell membranes, adding a new layer of intricacy to GPCR signaling. We previously reported the α

Indexed as

GPCRPDZ domainpharmacologyproteomicsscribblesyntrophin

Identifiers

PMID26617989
PMCPMC4658663
OpenAlexW2191432277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.