ReviewEplasty2015
Anticoagulants and Statins As Pharmacological Agents in Free Flap Surgery: Current Rationale.
Review in Eplasty, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Postoperative anticoagulation in patients with microvascular reconstruction - a systematic review.Oral and maxillofacial surgery · 2025Pooled it
- Antithrombotic Polymers: A Narrative Review on Current and Future Strategies for Their Design, Synthesis, and Application.International journal of molecular sciences · 2026Review
- Evidence-Based Approaches to Anticoagulation in Reconstructive Microsurgery-A Systematic Literature Review.Life (Basel, Switzerland) · 2024Review
- Full versus Baby Dose Aspirin for Antithrombotic Prophylaxis in Free Tissue Transfer: Does Size Matter?Plastic and reconstructive surgery. Global open · 2022Article
- Multidisciplinary Practice Variations of Anti-Thrombotic Strategies for Free Tissue Transfers.Plastic surgery (Oakville, Ont.) · 2022Article
- Surgical Reconstruction of Complex Distal Foot Defects With Vascularized Fascia Lata.Annals of plastic surgery · 2020Article
- Thromboprophylaxis in Head and Neck Microvascular Reconstruction.Craniomaxillofacial trauma & reconstruction · 2018Review
- Anaesthetic implications of free-flap microvascular surgery for head and neck malignancies - A relook.Journal of anaesthesiology, clinical pharmacologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microvascular free flaps are key components of reconstructive surgery, but despite their common use and usual reliability, flap failures still occur. Many pharmacological agents have been utilized to minimize risk of flap failure caused by thrombosis. However, the challenge of most antithrombotic therapy lies in providing patients with optimal antithrombotic prophylaxis without adverse bleeding effects. There is a limited but growing body of evidence suggesting that the vasoprotective and anti-inflammatory actions of statins can be beneficial for free flap survival. By inhibiting mevalonic acid, the downstream effects of statins include reduction of inflammation, reduced thrombogenicity, and improved vasodilation. This review provides a summary of the pathophysiology of thrombus formation and the current evidence of anticoagulation practices with aspirin, heparin, and dextran. In addition, the potential benefits of statins in the perioperative management of free flaps are highlighted.
Indexed as
Identifiers
26617953PMC4660317W2199373272What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.