ArticleInternational journal of clinical and experimental pathology2015
Distribution of HPV genotypes in Shanghai women.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Distribution of HPV types among women with HPV-related diseases and exploration of lineages and variants of HPV 52 and 58 among HPV-infected patients in China: A systematic literature review.Human vaccines & immunotherapeutics · 2024Pooled it
- The prevalence and genotype distribution of high-risk human papillomaviruses among women in Xianning, China.Virology journal · 2024Article
- Development of a machine learning-based model for predicting positive margins in high-grade squamous intraepithelial lesion (HSIL) treatment by Cold Knife Conization(CKC): a single-center retrospective study.BMC women's health · 2024Article
- Development of a simplified and cost-effective sample preparation method for genotyping of human papillomavirus by next-generation sequencing.Archives of virology · 2023Article
- The value of p16BMC women's health · 2022Article
- Research of cervical microbiota alterations with human papillomavirus infection status and women age in Sanmenxia area of China.Frontiers in microbiology · 2022Article
- Article
- The prevalence and genotype distribution of human papillomaviruses among women in Taizhou, China.Medicine · 2019Article
- Characteristics of carcinogenic HPV genotypes in North China Plain and the association with cervical lesions.Medicine · 2019Article
- Human papillomavirus in Ethiopia.Virusdisease · 2019Review
- Distribution of high-risk HPV types among women in Sichuan province, China: a cross-sectional study.BMC infectious diseases · 2019Article
- Prevalence and genotype distribution of human papillomavirus among 9945 women from the Nanhai area of Foshan.BMC infectious diseases · 2019Article
- Factors associated with human papillomavirus infection - findings from a cervical cancer screening program for female employees in Beijing.Cancer management and research · 2019Article
- Current issues facing the introduction of human papillomavirus vaccine in China and future prospects.Human vaccines & immunotherapeutics · 2019Review
- Association of HLA-DRB1/DQB1 polymorphism with high-risk HPV infection and cervical intraepithelial neoplasia women from Shanghai.International journal of clinical and experimental pathology · 2018Article
- Genotype distribution characteristics of multiple human papillomavirus in women from the Taihu River Basin, on the coast of eastern China.BMC infectious diseases · 2017Article
- Article
- HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability.Journal of experimental & clinical cancer research : CR · 2016Article
- Prevalence of human papillomavirus infection and genotyping for population-based cervical screening in developed regions in China.Oncotarget · 2016Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the Distribution of HPV genotypes in Shanghai women.
designCohort study.
settingShanghai First Maternity and Infant Hospital affiliated with Tongji University. POPULATION: Patients those attended in the cervical disease diagnosis and treatment center of Shanghai First Maternity and Infant Hospital between January 2011 and December 2014.
methodsHPV GenoArray test kit (HybriBio Ltd) was used to perform HPV genotyping and was also used in DNA amplification and HybriBio's proprietary flow-through hybridization technique.
resultsIn this study, total patients analyzed were 4585. Among 4585 sample the HPV positive patients were 1460 i.e. 31.84% in total. On the basis of pathological report normal were 1358, with inflammation 2441, with low grade lesion were 399, high grade lesion were 353, CIN were 19 and cervical carcinoma were 15. Among normal HPV positive were 215 (15.8%), among inflammation HPV positive were 735 (30.11%). HPV positive in low grade lesion were 353 i.e. 59.77%. In high grade lesion 211 were HPV positive among 272 (68.17%). The percentage of HPV positive was 73.68% i.e. 14 out of 19 patient in cervical carcinoma in situ. 13 patient out of 15 i.e. 86.67% of Cervical carcinoma were HPV positive. Among all percentage of HPV positive was high among cervical carcinoma then cervical carcinoma in situ then high grade lesion in decreasing fashion to low grade lesion and in normal. Highest prevalence i.e. 22.67% is of HPV 52 subtype and HPV 16 has second highest prevalence with 17.67% among HPV positive cases. Sensitivity of TCT detection is 71.6%. Specificity of TCT detection is 79.6%. Sensitivity of HPV-DNA detection is 65.2%. Specificity of HPV-DNA detection is 78.2%.
conclusionHPV is one of major health concern in shanghai having high prevalence rate in comparison to other part of china and other part of world. This has implications for the future cervical cancer burden and the priority to be given to prevent cervical cancer in Shanghai, especially, given the promising efficacy of prophylactic vaccines against HPV52, 16 and 58. This study also shows high sensitivity and specificity of TCT and HPV-DNA detection.
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