ArticleInternational journal of clinical and experimental pathology2015
Decreased pretreatment serum cholesterol level is related with poor prognosis in resectable non-small cell lung cancer.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Blood lipid metabolic biomarkers are emerging as significant prognostic indicators for survival in cancer patients.BMC cancer · 2024Pooled it
- Targeted metabolism creates possibilities for lung cancer treatment in the precision tumor era.Respiratory research · 2026Review
- Dietary ω-3 polyunsaturated fatty acids (PUFAs) reduce cholesterol-driven non-small cell lung cancer (NSCLC) progression in mouse models of disease.Communications medicine · 2025Article
- Controlling the nutritional status score: a new tool for predicting postoperative mortality in patients with infrarenal abdominal aortic aneurysm treated with endovascular aneurysm repair.Frontiers in nutrition · 2024Article
- Pre-existing cardiometabolic comorbidities and survival of middle-aged and elderly non-small cell lung cancer patients.Journal of geriatric cardiology : JGC · 2023Article
- The controlling nutritional status score predicts postoperative mortality in patients with ruptured abdominal aortic aneurysm: a retrospective study.Frontiers in cardiovascular medicine · 2023Article
- Prognostic significance of TG/HDL-C and non-HDL-C/HDL-C ratios in patients with non-small cell lung cancer: a retrospective study.The Journal of international medical research · 2022Article
- Proteomic analysis of plasma exosomes in patients with non-small cell lung cancer.Translational lung cancer research · 2022Article
- CONUT Score: A New Tool for Predicting Prognosis in Patients with Advanced Thyroid Cancer Treated with TKI.Cancers · 2022Article
- Cholesterol: An important actor on the cancer immune scene.Frontiers in immunology · 2022Review
- Prognostic value of the controlling nutritional status score in patients with myelodysplastic syndromes.Frontiers in nutrition · 2022Article
- Use of preoperative controlling nutritional status (CONUT) score as a better prognostic marker for distal cholangiocarcinoma after pancreatoduodenectomy.Surgery today · 2021Article
- The preoperative controlling nutritional status (CONUT) score is an independent prognostic marker for pancreatic ductal adenocarcinoma.Updates in surgery · 2021Article
- Prognostic nomogram integrated baseline serum lipids for patients with non-esophageal squamous cell carcinoma.Annals of translational medicine · 2019Article
- Combined Features Based on Preoperative Controlling Nutritional Status Score and Circulating Tumour Cell Status Predict Prognosis for Colorectal Cancer Patients Treated with Curative Resection.International journal of biological sciences · 2019Article
- Inhibition of Lung Tumor Development in ApoE Knockout Mice via Enhancement of TREM-1 Dependent NK Cell Cytotoxicity.Frontiers in immunology · 2019Article
- Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer.International journal of genomics · 2018Article
- High neutrophil-to-lymphocyte ratios confer poor prognoses in patients with small cell lung cancer.BMC cancer · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cholesterol has been reported to be associated with cancer development. The aim of our study was to investigate the serum cholesterol level (TC) in non-small cell lung cancer (NSCLC) patients and their association with clinicopathologic parameters and the prognosis. The serum cholesterol levels were evaluated in 259 resected NSCLC patients and were correlated with clinicopathologic variables including age, gender, tumor size, regional lymph node metastasis, disease-free survival time and overall survival time. Preoperative serum TC level was significantly associated with gender (P=0.001), smoking history (P=0.016), tumor differentiation (P=0.027), pT stage (P<0.001) and pN stage (P=0.009). Multivariate analyses indicated that decreased serum TC level was an independent prognostic factor for worse outcome. The hazard ratio was 1.89 (95% confidence interval [CI] 1.09-3.26) for disease progression and 2.19 (95% CI 1.01-4.74) for death. Based on this finding, the pretreatment serum cholesterol level is a novel independent prognostic biomarker in resectable NSCLC.
Indexed as
Identifiers
26617943PMC4637759W2405341926What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.