Evidence map›Paper›PMID 26617903›Full record

ArticleInternational journal of clinical and experimental pathology2015

Association between ERAP1 gene polymorphisms and ankylosing spondylitis susceptibility in Han population.

Jian Wang, Hang Li, Jianwei Wang, Xiang Gao

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jian WangDepartment of Orthopedics, The Second Hospital Affiliated to Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
Hang LiDepartment of Orthopedics, The Second Hospital Affiliated to Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
Jianwei WangDepartment of Orthopedics, The Second Hospital Affiliated to Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
Xiang GaoDepartment of Orthopedics, The Second Hospital Affiliated to Zhejiang University School of Medicine Hangzhou, Zhejiang, China.
Second Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposesThe present study was designed to investigate the relationship between endoplasmic reticulum amino peptidase 1 (ERAP1) gene polymorphisms and ankylosing spondylitis (AS) in Han population of Shaanxi province.

methods100 AS patients and 100 healthy people were enrolled in present study as case and control groups respectively, and the control group was matched with the case group by age and gender. ERAP1 gene rs27434 and rs7711564 polymorphisms were test by TaqMan probe genotyping method. SHEsis software was used to operate linkage disequilibrium (LD) and haplotype analysis between the two single nucleotide polymorphisms (SNPs). χ(2) test was employed to compare the differences of the genotype, allele and haplotype frequencies between the case and control groups. Relative risk of AS was represented by odds ratios (ORs) and 95% confidence intervals (95% CIs).

resultsIn ERAP1 rs27434 and rs7711564 polymorphisms, the frequencies of AA and CC genotypes in case group were significantly higher compared to those in control group (P=0.036; P=0.039), and so were the frequencies of A and C alleles (OR=1.589, 95% CI=1.070-2.359, P=0.028; OR=1.535, 95% CI=1.021-2.308, P=0.050). Linkage disequilibrium test and haplotype analysis of the alleles of the two SNPs showed that the frequency of A-C haplotype was higher in case group than that in control group (P=0.005), which indicated that A-C might be the susceptible haplotype to AS.

conclusionsERAP1 gene rs27434 and rs7711564 polymorphisms may increase the risk of AS.

Indexed as

AdolescentAdultAllelesAminopeptidasesAsian PeopleCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHaplotypesHumansMaleMiddle AgedMinor Histocompatibility AntigensPolymorphism, GeneticAminopeptidasesERAP1 protein, humanMinor Histocompatibility Antigensankylosing spondylitisERAP1haplotypepolymorphism

Identifiers

PMID26617903
PMCPMC4637719
OpenAlexW2394888965

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.