ArticleInternational journal of clinical and experimental pathology2015
Increased WNT6 expression in tumor cells predicts unfavorable survival in esophageal squamous cell carcinoma patients.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The Significance of the Wnt/β-Catenin Pathway and Related Proteins in Gastrointestinal Malignancies.International journal of molecular sciences · 2025Review
- Emerging roles and biomarker potential of WNT6 in human cancers.Cell communication and signaling : CCS · 2024Review
- Differential gene expression in cisplatin-resistant and -sensitive testicular germ cell tumor cell lines.Oncotarget · 2020Article
- Newly identified LMO3-BORCS5 fusion oncogene in Ewing sarcoma at relapse is a driver of tumor progression.Oncogene · 2019Article
- PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.Scientific reports · 2019Article
- High WNT6 expression indicates unfavorable survival outcome for patients with colorectal liver metastasis after liver resection.Journal of Cancer · 2019Article
- Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model.Oncotarget · 2018Article
- Genes and pathways associated with the occurrence of malignancy in benign lymphoepithelial lesions.Molecular medicine reports · 2018Article
- Article
- Esophageal Cancer: Genomic and Molecular Characterization, Stem Cell Compartment and Clonal Evolution.Medicines (Basel, Switzerland) · 2017Review
- Esophageal cancer stem cells and implications for future therapeutics.OncoTargets and therapy · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
WNT proteins are a family of secreted, cysteine-rich proteins containing 19 members. Signaling through WNT proteins is reported to be involved in carcinogenesis and cancer progression of gastrointestinal tumors, such as gastric cancer and colon cancer. The expression status of WNT6 in ESCCs and their clinico-prognostic significances remain to be elucidated. In this study, One-hundred and thirty-six patients with ESCC were explored. Paraffin-embedded tumor sections were stained with WNT6 antibody. The correlations between WNT6 expression and survival parameters were analyzed. The overall frequency of WNT6 over-expression was 50.7% (69/136) of advanced EC patients. For DMS and OS, over-expression of WNT6 remained the independent factor for worse prognosis (hazard ratio (HR), 2.425; 95% CI, 1.631-3.605; P < 0.001 for OS and HR, 2.238; 95% CI, 1.507-3.323; P < 0.001 for DMS, respectively). To conclude, our results support the concept that WNT6 may play a role in tumor progression. WNT6 over-expression inversely correlates with the poor long-term survival in ESCC patients. WNT6 can be considered as a predictor for recurrence.
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26617869PMC4637685What OpenQuestion holds
Registered trials
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