ArticleKorean circulation journal2015
T-Helper Cytokine Profiles in Patients with Kawasaki Disease.
Article in Korean circulation journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The Roles of Genetic Factors in Kawasaki Disease: A Systematic Review and Meta-analysis of Genetic Association Studies.Pediatric cardiology · 2018Pooled it
- Overview of T-cell subsets and related cytokines in Kawasaki disease.Pediatric research · 2026Review
- Immunological Profile in Atypical Kawasaki Disease: A Case Report Highlighting the Diagnostic Utility of Cytokine Analysis by qRT-PCR.Pediatric reports · 2025Article
- Kawasaki disease: insights into the roles of T cells.Frontiers in immunology · 2025Review
- Basophils Predict Mite Sensitization in Patients with Kawasaki Disease.Children (Basel, Switzerland) · 2023Article
- Expression of Eosinophilic Subtype Markers in Patients with Kawasaki Disease.International journal of molecular sciences · 2022Article
- Breastfeeding has no protective effects on the development of coronary artery lesions in Kawasaki disease: a retrospective cohort study.BMC pediatrics · 2022Article
- Intravenous Immunoglobulin Therapy Restores the Quantity and Phenotype of Circulating Dendritic Cells and CD4Frontiers in immunology · 2022Article
- The Impact of Moderate-Dose Acetylsalicylic Acid in the Reduction of Inflammatory Cytokine and Prevention of Complication in Acute Phase of Kawasaki Disease: The Benefit of Moderate-Dose Acetylsalicylic Acid.Children (Basel, Switzerland) · 2020Article
- Adjuvant herbal therapy for targeting susceptibility genes to Kawasaki disease: An overview of epidemiology, pathogenesis, diagnosis and pharmacological treatment of Kawasaki disease.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2020Review
- Kawasaki Disease and Multisystem Inflammatory Syndrome in Children with COVID-19.SN comprehensive clinical medicine · 2020Review
- Epigenetic Regulation of Macrophage Marker Expression Profiles in Kawasaki Disease.Frontiers in pediatrics · 2020Article
- Article
- Kawasaki Disease and Allergic Diseases.Frontiers in pediatrics · 2020Review
- Distribution of distinct subsets of circulating T follicular helper cells in Kawasaki disease.BMC pediatrics · 2019Article
- Kawasaki disease shock syndrome: clinical characteristics and possible use of IL-6, IL-10 and IFN-γ as biomarkers for early recognition.Pediatric rheumatology online journal · 2019Article
- TheJournal of immunology research · 2019Article
- Article
- The CXCL10/CXCR3 Axis and Cardiac Inflammation: Implications for Immunotherapy to Treat Infectious and Noninfectious Diseases of the Heart.Journal of immunology research · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesKawasaki disease is an acute systemic vasculitis of which pathogenesis suspected is caused by immune dysregulation. The goal of this study is to evaluate the activation pattern of T helper cell type 1 (Th1) and T helper cell type 2 (Th2) in patients with Kawasaki disease. SUBJECTS AND
methodsProspective study of 60 patients (male 36, female 24) with diagnosis of Kawasaki disease were enrolled. One hundred and eighty blood samples from these patients were collected according to the different clinical stages {before initial intravenous immunoglobulin (IVIG), 5 days after initial IVIG, 2 months after initial IVIG}. The plasma level of Th1 cytokines; interferon-gamma (IFN-γ) & interleukin (IL)-2 and Th2 cytokines; IL-4 & IL-10 were measured by enzyme-liked immunosorbent assay.
resultsIn all patients, the plasma level of Th1 cytokines (IFN-γ, IL-2) and Th2 cytokines (IL-4 and IL-10) were markedly elevated during the acute stage of Kawasaki disease. Since then, the plasma level of all these cytokines decreased significantly along with the process of clinical stages. Regardless of the existence of coronary artery lesion or no response to initial IVIG treatment, there were no significant differences between them.
conclusionThese data suggest that both Th1 and Th2 cells may be activated simultaneously during the acute stage of Kawasaki disease. Further studies are therefore required to establish the difference of activation pattern of T helper cells between Kawasaki disease and other inflammatory diseases.
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