ReviewFrontiers in microbiology2015
On the (Un)greenness of Biocatalysis: Some Challenging Figures and Some Promising Options.
Review in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Redox Biocatalysis in Lidocaine-Based Hydrophobic Deep Eutectic Solvents: Non-Conventional Media Outperform Aqueous Conditions.ChemSusChem · 2025Article
- Solvent Engineering for Nonpolar Substrate Glycosylation Catalyzed by the UDP-Glucose-Dependent Glycosyltransferase UGT71E5: Intensification of the Synthesis of 15-Hydroxy Cinmethylin β-d-Glucoside.Journal of agricultural and food chemistry · 2023Article
- Biocatalysis in Water or in Non-Conventional Media? Adding the COMolecules (Basel, Switzerland) · 2023Article
- Tyrosinase Magnetic Cross-Linked Enzyme Aggregates: Biocatalytic Study in Deep Eutectic Solvent Aqueous Solutions.Biomolecules · 2023Article
- Assessment of New and Genome-ReducedMicroorganisms · 2023Article
- Review
- Replacement of Less-Preferred Dipolar Aprotic and Ethereal Solvents in Synthetic Organic Chemistry with More Sustainable Alternatives.Chemical reviews · 2022Review
- Deep Eutectic Solvents in Solar Energy Technologies.Molecules (Basel, Switzerland) · 2022Review
- Design of fusion enzymes for biocatalytic applications in aqueous and non-aqueous media.Frontiers in bioengineering and biotechnology · 2022Review
- Two-Phase Biocatalysis in Microfluidic Droplets.Biosensors · 2021Article
- Segmented Flow Processes to Overcome Hurdles of Whole-Cell Biocatalysis in the Presence of Organic Solvents.Angewandte Chemie (International ed. in English) · 2021Article
- Applied biocatalysis beyond just buffers - from aqueous to unconventional media. Options and guidelines.Green chemistry : an international journal and green chemistry resource : GC · 2021Review
- Biocatalyzed Redox Processes Employing Green Reaction Media.Molecules (Basel, Switzerland) · 2020Review
- Modeling Alcohol Dehydrogenase Catalysis in Deep Eutectic Solvent/Water Mixtures.Chembiochem : a European journal of chemical biology · 2020Article
- The Versatile Applications of DES and Their Influence on Oxidoreductase-Mediated Transformations.Molecules (Basel, Switzerland) · 2019Review
- Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-ACS catalysis · 2018Article
- Two-Component FAD-Dependent Monooxygenases: Current Knowledge and Biotechnological Opportunities.Biology · 2018Review
- Deep Eutectic Solvents as Novel and Effective Extraction Media for Quantitative Determination of Ochratoxin A in Wheat and Derived Products.Molecules (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biocatalysis is generally regarded as a "green" technology. This statement is justified by the mild reaction conditions, the use of aqueous reaction media-with water as the paradigm of green solvents-, and the renewable nature of the biocatalysts. However, researchers making these statements frequently do not take into account the entire picture of their processes. Aspects like water consumption, wastewater production, titers, and metrics of the (diluted?) biocatalytic processes are important as well. With those figures at hand, many biocatalytic reactions do not appear so green anymore. This article critically discusses some common wrong assumptions given for biocatalytic approaches, with regard to their environmental impact, and actual greenness. Some promising biocatalytic approaches, such as the use of biphasic systems involving biogenic solvents, deep-eutectic-solvents (and biogenic ionic liquids), water-free media, solvent-free processes, are briefly introduced, showing that enzyme catalysis can actually be a robust sustainable alternative for chemical processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.