ArticleFrontiers in microbiology2015
Characterization of a CTX-M-15 Producing Klebsiella Pneumoniae Outbreak Strain Assigned to a Novel Sequence Type (1427).
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
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- Isolation and Characterization of Extended-Spectrum β-Lactamase ProducingIndian journal of microbiology · 2024Article
- Genetic Analyses of Rare ESBL ST628Microorganisms · 2024Article
- Taxonomic Assignment-Based Genome Reconstruction from Apical Periodontal Metagenomes to Identify Antibiotic Resistance and Virulence Factors.Life (Basel, Switzerland) · 2023Article
- Application of next-generation sequencing to identify different pathogens.Frontiers in microbiology · 2023Review
- Intestinal colonization with ESBL-producingFrontiers in public health · 2022Article
- Characterization of ESBL-ProducingMicroorganisms · 2021Article
- Genomic analysis revealing the resistance mechanisms of extended-spectrum β-lactamase-producing Klebsiella pneumoniae isolated from pig and humans in Malaysia.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Article
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- Co-Production of NDM-1, CTX-M-9 Family and mcr-1 in aInfection and drug resistance · 2021Article
- Multidrug-resistant Klebsiella pneumoniae harboring extended spectrum β-lactamase encoding genes isolated from human septicemias.PloS one · 2021Article
- BacAnt: A Combination Annotation Server for Bacterial DNA Sequences to Identify Antibiotic Resistance Genes, Integrons, and Transposable Elements.Frontiers in microbiology · 2021Article
- Whole Genome Sequencing of PediatricFrontiers in microbiology · 2021Article
- COVID-19 diagnostic testing: Technology perspective.Clinical and translational medicine · 2020Article
- Whole Genome Sequencing of Extended Spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae Isolated from Hospitalized Patients in KwaZulu-Natal, South Africa.Scientific reports · 2019Article
- Core/Whole Genome Multilocus Sequence Typing and Core Genome SNP-Based Typing of OXA-48-ProducingFrontiers in microbiology · 2019Article
- Whole Genome Sequence Analysis of CTX-M-15 ProducingFrontiers in microbiology · 2018Article
- Integrated Stewardship Model Comprising Antimicrobial, Infection Prevention, and Diagnostic Stewardship (AID Stewardship).Journal of clinical microbiology · 2017Article
- Article
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8 authors.
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Abstract
Extended-spectrum -lactamase producing Klebsiella pneumoniae have emerged as one of the major nosocomial pathogens. Between July and September 2012, a CTX-M-15 producing K. pneumoniae caused an outbreak in a university hospital in the Netherlands. The outbreak isolates were characterized and assigned to a novel sequence type (ST1427). An epidemiological link between affected patients was supported by patient contact tracing and whole-genome phylogenetic analysis. Intra-strain polymorphism was detected among multiple isolates obtained from different body sites of the index patient, which may relate to antibiotic treatment and/or host adaptation. Environmental contamination caused by the outbreak clone was found in the patient rooms even on medical equipment. The novel clone was not closely related to any known endemic/epidemic clone, but carried a set of a plasmid-borne resistance genes [bla CTX-M-15, bla TEM-1, bla OXA-1, aac(6')-Ib-cr, qnrB1, tetA(A), aac(3)-II]. Analysis of its virulence factors revealed a previously uncharacterized capsular biosynthesis region and two uncharacterized fimbriae gene clusters, and suggested that the new clone was not hypervirulent. To our knowledge, this is the first outbreak report of K. pneumoniae ST1427, and our study could be of help to understand the features of this newly emerging clone.
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