Evidence map›Paper›PMID 26617521›Full record

ReviewFrontiers in pharmacology2015

Luminal Conversion and Immunoregulation by Probiotics.

Bhanu Priya Ganesh, James Versalovic

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bhanu Priya GaneshDepartment of Pathology and Immunology, Baylor College of Medicine , Houston, TX, USA ; Department of Pathology, Texas Children's Hospital , Houston, TX, USA.
James VersalovicDepartment of Pathology and Immunology, Baylor College of Medicine , Houston, TX, USA ; Department of Pathology, Texas Children's Hospital , Houston, TX, USA.
Baylor College of Medicine · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
The Human Microbiome in Pediatric Abdominal Pain and Intestinal InflammationUH3DK083990 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2010 to 2012
$3.3M
Gut L-Histidine Metabolism and Histamine Signaling in Colonic NeoplasiaU01CA170930 · NCI · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2013 to 2017
$2.8M
Modulation of NF-kB Signaling by ImmunoprobioticsR01AT004326 · NCCIH · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2008 to 2011
$1.8M
Intestinal Lactobacillus and Mucosal ImmunomodulationR01DK065075 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2007 to 2010
$1.3M
NCCIH NIH HHS R01 AT004326NCI NIH HHS U01 CA170930NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK065075NIDDK NIH HHS UH3 DK083990
6 · The paper itself

Abstract

Beneficial microbes are responsible for the synthesis of nutrients and metabolites that are likely important for the maintenance of mammalian health. Many nutrients and metabolites derived from the gut microbiota by luminal conversion have been implicated in the development, homeostasis and function of innate and adaptive immunity. These factors clearly suggest that intestinal microbiota may influence host immunity via microbial metabolite-dependent mechanisms. We describe how intestinal microbes including probiotics generate microbial metabolites that modulate mucosal and systemic immunity.

Indexed as

commensal bacteriadietdietary compoundsimmunomodulationmetabolitesmicrobiomeprobiotics

Identifiers

PMID26617521
PMCPMC4641912
OpenAlexW2162359074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.